| Arginyl-Glutamine (Arg-Gln) Dipeptide or Docosahexaenoic Acid (DHA) Attenuate Hyperoxia-Induced Small Intestinal Injury in Neonatal Mice. | |
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MedLine Citation:
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PMID: 22020559 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND:: Supplementation studies of glutamine, arginine and docosahexaenoic acid (DHA) have established the safety of each of these nutrients in neonates. However, the potential for a more stable and soluble dipeptide, Arginyl-Glutamine (Arg-Gln) or DHA with anti-inflammatory properties, to exert benefits on hyperoxia-induced intestinal injury has not been investigated. Arg-Gln dipeptide has shown benefits in preventing retinal damage in a rodent model of oxygen-induced injury. OBJECTIVE:: To investigate whether Arg-Gln dipeptide or DHA could also attenuate markers of injury and inflammation to the small intestine in this same model. METHODS:: Seven-day-old mouse pups were placed with their dams in 75% oxygen for 5-days. After 5-days of hyperoxic exposure (P7-P12), pups were removed from hyperoxia and allowed to recover in atmospheric conditions for 5-days (P12-P17). Mouse pups received Arg-Gln (5 g/kg/d) or DHA (5 g/kg/d) or vehicle orally started on P12 through P17. DSI histologic changes, myeloperoxidase (MPO), lactate dehydrogenase (LDH) and inflammatory cytokines and tissue apoptosis were evaluated. RESULTS:: Hyperoxia mice showed a greater distortion of overall villus structure and with higher injury score (p < 0.05). Arg-Gln dipeptide and DHA supplementation groups were more similar to the room air control group. Supplementation of Arg-Gln or DHA reduced hyperoxia induced MPO activity (P < 0.05). Supplementation of Arg-Gln or DHA returned LDH activity to levels of control. Hyperoxia induced apoptotic cell death in DSI, both Arg-Gln and DHA reversed this effect (P < 0.05). CONCLUSIONS:: Supplementation with either Arg-Gln or DHA may limit some inflammatory and apoptotic processes involved in hyperoxic-induced intestinal injury in neonatal mice. |
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Authors:
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Nan Li; Liya Ma; Xueyan Liu; Lynn Shaw; Sergio Li Calzi; Maria Grant; Josef Neu |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: - ISSN: 1536-4801 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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*Department of Pediatrics †Department of Pharmacology, University of Florida, Gainesville, FL 32610 ‡Department of Neonatology Shenzhen Baoan Maternity and Child Health Hospital, Shenzhen, 518133 China §Sheng Jing Hospital, China Medical University, Shenyang, 110004 China. 1The two authors contributed equally to this work. |
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