Document Detail


Arginine and vitamin E modulate the subpopulations of T lymphocytes in broiler chickens.
MedLine Citation:
PMID:  18079449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the effects of vitamin E (VE) and Arg on the subpopulations of T lymphocytes in peripheral blood after an infectious bursal disease virus vaccination (20 d old, n = 54). Broiler chickens were fed diets with normal levels of Arg (NARG, 1.2%) or high levels of Arg (HARG, 2.2%) and 3 levels of VE (40, 80, or 200 IU/kg of feed) in a factorial arrangement of treatments. The percentages of CD4+ and CD8+ cells 9 d after vaccination were not different in birds fed the HARG or NARG feed, but they were higher in birds fed the VE80 diet than in birds fed the VE40 diet. Birds fed the VE200 feed had similar levels of CD4+ and CD8+ cells as birds fed the VE40 diet. However, 19 d after vaccination, the percentage of CD4+ cells was higher in birds fed the HARG (43.93 +/- 1.05) diet than in birds fed the NARG diet (41.14 +/- 1.05) and in birds fed the VE80 and VE200 (44.1 +/- 1.28 and 44.42 +/- 1.28, respectively) diets compared with birds fed the VE40 diet (39.04 +/- 1.28). On the other hand, the percentage of CD8+ cells was highest in birds fed the HARG-VE80 feed compared with all the other Arg and VE combinations. The percentages of CD3+ cells and BU-1+ cells were higher in birds fed the HARG (81.35 +/- 1.46 and 22.3 +/- 0.89, respectively) diet than in birds fed the NARG diets (77.82 +/- 1.46 and 18.93 +/- 0.89, respectively). Birds fed the VE40 had a higher amount of BU-1+ (24.35 +/- 1.073) but lower amounts of CD3+ cells (75.76 +/- 1.76) than birds fed the VE80 (18.46 +/- 1.073 and 81.67 +/- 1.76) and VE200 (19.03 +/- 1.073 and 81.19 +/- 1.76, respectively). Neither Arg nor VE had an effect on the CD4+:CD8+ cell ratio and on the percentage of immature (CD4+CD8+) T lymphocytes 9 d after vaccination. These results suggest that Arg and VE have complimentary effects on cellular and humoral immune function and may enhance the resistance of broilers to infectious diseases.
Authors:
S T Abdukalykova; X Zhao; C A Ruiz-Feria
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Poultry science     Volume:  87     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-14     Completed Date:  2008-02-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Affiliation:
Department of Animal Science, McGill University, Ste Anne de Bellevue, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / pharmacology*
CD4-CD8 Ratio / veterinary
CD4-Positive T-Lymphocytes / drug effects*,  immunology
CD8-Positive T-Lymphocytes / drug effects*,  immunology
Chickens / immunology*
Infectious bursal disease virus / immunology
Random Allocation
Tocopherols
Vaccination / methods,  veterinary
Viral Vaccines / immunology
alpha-Tocopherol / analogs & derivatives*,  pharmacology
Chemical
Reg. No./Substance:
0/Viral Vaccines; 1406-66-2/Tocopherols; 59-02-9/alpha-Tocopherol; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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