| Arginine vasopressin does not mediate the attenuated febrile response to intravenous IL-1beta in pregnant rats. | |
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MedLine Citation:
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PMID: 9950924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats have an attenuated febrile response to intravenous endogenous pyrogen [e.g., interleukin-1beta (IL-1beta)] near the term of pregnancy. The present experiments were carried out on 25 nonpregnant and 32 pregnant rats to test the hypothesis that arginine vasopressin functioning as an endogenous antipyretic substance in the central nervous system mediates this attenuated febrile response. An intravenous injection of recombinant rat IL-1beta (rrIL-1beta) after intracerebroventricular vehicle produced a significant increase in core temperature in both nonpregnant and pregnant animals, the magnitude and duration of which was greater in the nonpregnant rats. In nonpregnant rats, intravenous rrIL-1beta after intracerebroventricular vasopressin V1-receptor antagonist accentuated the core temperature response compared with that observed with intravenous rrIL-1beta after intracerebroventricular vehicle. In pregnant animals, however, intravenous rrIL-1beta after intracerebroventricular vasopressin V1-receptor antagonist produced a decrease in core temperature rather than an increase in core temperature, which was observed with intravenous rrIL-1beta after intracerebroventricular vehicle. Thus our data do not support the hypothesis that a pregnancy-related activation of arginine vasopressin as an endogenous antipyretic substance in the central nervous system attenuates the febrile response to intravenous rrIL-1beta near the term of pregnancy in rats. |
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Authors:
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H L Eliason; J E Fewell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 276 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-03-30 Completed Date: 1999-03-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R450-4 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, Health Sciences Centre, The University of Calgary, Calgary, Alberta, Canada T2N 4N1. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / physiology* Body Temperature / drug effects Female Fever / chemically induced*, physiopathology* Injections, Intravenous Injections, Intraventricular Interleukin-1* Pregnancy Pregnancy, Animal / physiology* Rats Rats, Sprague-Dawley Receptors, Vasopressin / antagonists & inhibitors Recombinant Proteins |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Receptors, Vasopressin; 0/Recombinant Proteins; 113-79-1/Arginine Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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