Document Detail

Arginine supplementation prevents necrotizing enterocolitis in the premature infant.
MedLine Citation:
PMID:  12006956     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine whether supplementation with L -arginine reduces the incidence of all stages of necrotizing enterocolitis (NEC) in premature infants with birth weight < or =1250 g and gestational age < or =32 weeks. STUDY DESIGN: In a randomized, double-blind, placebo-controlled study, 152 premature infants were prospectively, randomly assigned to receive either supplemental L -arginine (1.5 mmol/kg per day; n =75 [group A]) or placebo (control group; n = 77 [group B]) with oral feeds/parenteral nutrition during the first 28 days of life. Nutrient intake, plasma ammonia, arginine, and amino acid concentrations were measured in all infants at days 3, 14, and 28 and at the time of diagnosis of NEC. RESULTS: NEC developed in 5 infants in group A compared with 21 infants in group B (P <.001). Arginine intake and plasma arginine concentrations were similar in both groups at study entry and (as expected) increased in group A at days 14 and 28. Plasma arginine concentrations were lower in both groups at time of diagnosis of NEC. No significant differences in maternal and neonatal demographics, nutrient intake, plasma ammonia and total and essential amino acid concentrations were present between the two groups. CONCLUSIONS: Arginine supplementation (1.5 mmol/kg per day) in premature infants reduces the incidence of all stages of NEC.
Harish J Amin; Samuel A Zamora; Douglas D McMillan; Gordon H Fick; J Decker Butzner; Howard G Parsons; R Brent Scott
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  140     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-05-13     Completed Date:  2002-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-31     Citation Subset:  AIM; IM    
Division of Neonatology, Department of Pediatrics, The University of Calgary, Calgary, Alberta, Canada.
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MeSH Terms
Arginine / blood,  therapeutic use*
Canada / epidemiology
Dietary Supplements*
Double-Blind Method
Enterocolitis, Necrotizing / blood,  epidemiology,  therapy*
Gestational Age
Glutamine / blood
Infant Welfare
Infant, Newborn
Infant, Premature*
Infant, Very Low Birth Weight
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
56-85-9/Glutamine; 74-79-3/Arginine
Comment In:
J Pediatr. 2002 Apr;140(4):389-91   [PMID:  12006949 ]

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