Document Detail

The Arginine Catabolic Mobile Element is associated with low antibiotic resistance and low pathogenicity in Staphylococcus epidermidis from neonates.
MedLine Citation:
PMID:  20531253     Owner:  NLM     Status:  Publisher    
The arginine catabolic mobile element (ACME) in staphylococci encodes several putative virulence factors. ACME appears to have been transferred from Staphylococcus epidermidis into Staphylococcus aureus and is strongly associated with the epidemic and virulent S. aureus USA300. We sought to determine the distribution of ACME in 128 S. epidermidis blood culture isolates from neonates and to assess ACME's impact on antibiotic resistance, biofilm production, invasive capacity and host inflammatory response. ACME was detected in 15/64 (23%) invasive blood culture isolates and 26/64 (40%) blood culture contaminants (p = 0.02). ACME-positive S. epidermidis isolates displayed less antibiotic resistance (p < 0.001) and were collected from more mature neonates (p = 0.001). Biofilm production was more prevalent among ACME-negative isolates (61/87) compared with ACME-positive (18/41) (p = 0.004). Among the 64 children considered having an invasive infection ACME did not influence the maximum C-reactive protein level. In an in vitro whole-blood sepsis model there were no differences in the inflammatory response between ACME-positive and ACME-negative isolates. We conclude that ACME in S. epidermidis from neonates was associated with less antibiotic resistance and also does not appear to be associated with increased pathogenicity. ABBREVIATIONS:
Hildegunn Norbakken Granslo; Claus Klingenberg; Elizabeth Gladys Aarag Fredheim; Arild Rønnestad; Tom Eirik Mollnes; Trond Flægstad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-6-7
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  -     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-6-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Pediatrics [H.N.G., C.K., E.G.A.F., T.F.], Institute of Medical Biology [T.E.M.], University of Tromsø, N-9037 Tromsø, Norway; Department of Pediatrics [C.K., T.F.], Division of Child Health, University Hospital of North Norway, N-9038 Tromsø, Norway; Department of Pediatrics [A.R.], Oslo University Hospital, Rikshospitalet, N-0027 Oslo, Norway; Research Laboratory [T.E.M.], Nordland Hospital, N-8092 Bodø, Norway.
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