Document Detail

Arginase: marker, effector, or candidate gene for asthma?
MedLine Citation:
PMID:  12813015     Owner:  NLM     Status:  MEDLINE    
Microarray analysis of the expression profiles of lung tissue in two murine models of asthma revealed high levels of arginase I and arginase II activity, in association with IL-4 and IL-13 overexpression, suggesting that arginine pathways are critical in the pathogenesis of asthma.
Donata Vercelli
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  111     ISSN:  0021-9738     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-18     Completed Date:  2003-08-06     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1815-7     Citation Subset:  AIM; IM    
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724-5030, USA.
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MeSH Terms
Arginase / genetics*
Arginine / physiology
Asthma / enzymology*,  etiology,  genetics*
Gene Expression Profiling
Genetic Markers
Isoenzymes / genetics
Lung / enzymology
Nitric Oxide / physiology
Oligonucleotide Array Sequence Analysis
Reg. No./Substance:
0/Genetic Markers; 0/Isoenzymes; 10102-43-9/Nitric Oxide; 74-79-3/Arginine; EC
Comment On:
J Clin Invest. 2003 Jun;111(12):1863-74   [PMID:  12813022 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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