Document Detail

Arginase increases total pancreatic and islet blood flow in anaesthetized mice.
MedLine Citation:
PMID:  17578816     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies have demonstrated that the high basal pancreatic islet blood perfusion is crucially dependent on nitric oxide formation. Arginase can interfere with the formation of nitric oxide by limiting substrate availability. The aim of the present study was to evaluate the influence of arginase on islet blood perfusion in anaesthetized mice. METHODS: The blood perfusion of the pancreatic islets was measured with a microsphere technique in anaesthetized NMRI mice after administration of arginase. RESULTS: Arginase administration increased both total pancreatic and islet blood flow to the same degree. Also adrenal blood flow was increased, whereas other organ blood flow values were unaffected. CONCLUSION: Arginase induces a paradoxical increase in pancreatic and islet blood flow, the reasons for which are still unknown.
Leif Jansson; Birgitta Bodin; Orjan Källskog
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Upsala journal of medical sciences     Volume:  112     ISSN:  2000-1967     ISO Abbreviation:  Ups. J. Med. Sci.     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-20     Completed Date:  2008-08-11     Revised Date:  2009-03-02    
Medline Journal Info:
Nlm Unique ID:  0332203     Medline TA:  Ups J Med Sci     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  165-73     Citation Subset:  IM    
Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Arginase / pharmacology*
Blood Glucose / analysis
Insulin / blood
Islets of Langerhans / blood supply,  drug effects*
Nitric Oxide / biosynthesis
Pancreas / blood supply,  drug effects*
Reg. No./Substance:
0/Blood Glucose; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; EC

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