| Arginase increases total pancreatic and islet blood flow in anaesthetized mice. | |
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MedLine Citation:
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PMID: 17578816 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies have demonstrated that the high basal pancreatic islet blood perfusion is crucially dependent on nitric oxide formation. Arginase can interfere with the formation of nitric oxide by limiting substrate availability. The aim of the present study was to evaluate the influence of arginase on islet blood perfusion in anaesthetized mice. METHODS: The blood perfusion of the pancreatic islets was measured with a microsphere technique in anaesthetized NMRI mice after administration of arginase. RESULTS: Arginase administration increased both total pancreatic and islet blood flow to the same degree. Also adrenal blood flow was increased, whereas other organ blood flow values were unaffected. CONCLUSION: Arginase induces a paradoxical increase in pancreatic and islet blood flow, the reasons for which are still unknown. |
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Authors:
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Leif Jansson; Birgitta Bodin; Orjan Källskog |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Upsala journal of medical sciences Volume: 112 ISSN: 2000-1967 ISO Abbreviation: Ups. J. Med. Sci. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-06-20 Completed Date: 2008-08-11 Revised Date: 2009-03-02 |
Medline Journal Info:
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Nlm Unique ID: 0332203 Medline TA: Ups J Med Sci Country: Sweden |
Other Details:
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Languages: eng Pagination: 165-73 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden. Leif.Jansson@medcellbiol.uu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia* Animals Arginase / pharmacology* Blood Glucose / analysis Insulin / blood Islets of Langerhans / blood supply, drug effects* Male Mice Nitric Oxide / biosynthesis Pancreas / blood supply, drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 10102-43-9/Nitric Oxide; 11061-68-0/Insulin; EC 3.5.3.1/Arginase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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