| Argatroban therapy for heparin-induced thrombocytopenia during pregnancy in a woman with hereditary antithrombin deficiency. | |
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MedLine Citation:
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PMID: 22380425 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A 33-year-old woman developed deep venous thrombosis at 7 gestational weeks (GW). Heparin-induced thrombocytopenia was evident at 9 GW during unfractionated heparin infusion. Immediately, anticoagulation therapies together with antithrombin (AT) infusion were commenced with the use of argatroban from 9 GW, and fondaparinux was substituted for argatroban after 24 GW. The patient had hereditary AT deficiency type I determined by laboratory findings and results of genomic DNA analysis. The pregnancy ended in full-term vaginal delivery of a healthy male without adverse effects of the anticoagulation therapies. This was the first report of a pregnant woman who developed heparin-induced thrombocytopenia caused by heparin therapy for deep venous thrombosis due to AT deficiency. |
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Authors:
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Kenji Tanimura; Yashuhiko Ebina; Ayako Sonoyama; Hiroki Morita; Shigeki Miyata; Hideto Yamada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-2 |
Journal Detail:
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Title: The journal of obstetrics and gynaecology research Volume: - ISSN: 1447-0756 ISO Abbreviation: J. Obstet. Gynaecol. Res. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612761 Medline TA: J Obstet Gynaecol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology. |
Affiliation:
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Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe Division of Transfusion Medicine, National Cerebral and Cardiovascular Center, Suita, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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