Document Detail

Argatroban anticoagulation for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of heparin-induced thrombocytopenia.
MedLine Citation:
PMID:  18715467     Owner:  NLM     Status:  MEDLINE    
Heparin-induced thrombocytopenia (HIT) is a life-threatening complication of heparin therapy. Anticoagulation in pediatric patients with HIT is challenging as there are no approved heparin substitutes. We report the use of the anticoagulant argatroban for cardiac surgery with cardiopulmonary bypass in an infant with double outlet right ventricle and a history of HIT.
Michael L Ciccolo; Jonathan Bernstein; Juan C Collazos; Ruben J Acherman; Humberto Restrepo; James M Winters; Justin Krueger; William N Evans
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Congenital heart disease     Volume:  3     ISSN:  1747-0803     ISO Abbreviation:  Congenit Heart Dis     Publication Date:    2008 Jul-Aug
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-10-28     Revised Date:  2011-05-05    
Medline Journal Info:
Nlm Unique ID:  101256510     Medline TA:  Congenit Heart Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  299-302     Citation Subset:  IM    
Cardiothoracic Surgery, Cardiovascular Surgical Associates, Las Vegas, Nevada, USA.
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MeSH Terms
Anticoagulants / administration & dosage,  adverse effects,  therapeutic use*
Blood Vessel Prosthesis Implantation
Cardiopulmonary Bypass
Child, Preschool
Double Outlet Right Ventricle / surgery*
Ductus Arteriosus, Patent / surgery
Heparin / adverse effects
Pipecolic Acids / administration & dosage,  therapeutic use*
Pulmonary Valve Stenosis / surgery
Thrombocytopenia / chemically induced
Reg. No./Substance:
0/Anticoagulants; 0/Pipecolic Acids; 74863-84-6/argatroban; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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