| The Arg389Gly beta1-adrenoceptor polymorphism does not affect cardiac effects of exercise after parasympathetic inhibition by atropine. | |
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MedLine Citation:
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PMID: 16344717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In vitro, Arg389Gly beta1-adrenoceptor (AR) polymorphism exhibits decreased beta-AR signalling. In vivo, beta1-AR-mediated cardiac effects of exercise showed no genotype-dependent differences in Arg389 vs. Gly389 beta1-AR subjects. We studied in 16 male subjects homozygous Arg389 or Gly389 beta1-AR, whether blockade of parasympathetic activity might unmask genotype-dependence of exercise effects. Subjects were infused with atropine (10 microg/kg i.v. loading dose followed by continuous i.v. infusion of 0.15 microg/kg/min throughout exercise-time); 20 min after start of atropine bicycle-exercise in supine position (25, 50, 75 and 100 W for 5 min each) was performed and heart rate, contractility, blood pressure, plasma noradrenaline and plasma-renin activity were assessed. Exercise-evoked increases in all but one parameters were not different between Arg389 and Gly389 beta1-AR subjects; only plasma noradrenaline increased slightly more in Gly389 vs. Arg389 beta1-AR subjects. In conclusion: It appears to be unlikely that lack of Arg389Gly beta1-AR genotype-dependence of exercise-effects can be explained by influences of parasympathetic activity. |
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Authors:
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Kirsten Leineweber; Heike Bruck; Thomas Temme; Gerd Heusch; Thomas Philipp; Otto-Erich Brodde |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacogenetics and genomics Volume: 16 ISSN: 1744-6872 ISO Abbreviation: Pharmacogenet. Genomics Publication Date: 2006 Jan |
Date Detail:
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Created Date: 2005-12-13 Completed Date: 2006-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101231005 Medline TA: Pharmacogenet Genomics Country: United States |
Other Details:
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Languages: eng Pagination: 9-13 Citation Subset: IM |
Affiliation:
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Department of Nephrology, University of Essen Medical School, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Substitution Antihypertensive Agents / blood, pharmacology* Arginine / genetics Atropine / blood, pharmacology* Blood Pressure / drug effects Exercise / physiology* Glycine / genetics Heart Rate / drug effects Humans Parasympathetic Nervous System / drug effects*, physiology Polymorphism, Genetic Receptors, Adrenergic, beta-1 / chemistry, genetics*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Receptors, Adrenergic, beta-1; 51-55-8/Atropine; 56-40-6/Glycine; 74-79-3/Arginine |
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