| Area-specific modulation of neural activation comparing escitalopram and citalopram revealed by pharmaco-fMRI: a randomized cross-over study. | |
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MedLine Citation:
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PMID: 19833214 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Area-specific and stimulation-dependent changes of human brain activation by selective serotonin reuptake inhibitors (SSRI) are an important issue for improved understanding of treatment mechanisms, given the frequent prescription of these drugs in depression and anxiety disorders. The aim of this neuroimaging study was to investigate differences in BOLD-signal caused by administration of the SSRIs escitalopram and citalopram using pharmacological functional magnetic resonance imaging (pharmaco-fMRI). Eighteen healthy subjects participated in a placebo-controlled, randomized, double-blind study in cross-over repeated measures design. Each volunteer performed facial emotional discrimination and a sensorimotor control paradigm during three scanning sessions. Citalopram (20 mg/d), escitalopram (10 mg/d) and placebo were administered for 10 days each with a drug-free period of at least 21 days. Significant pharmacological effects on BOLD-signal were found in the amygdala, medial frontal gyrus, parahippocampal, fusiform and middle temporal gyri. Post-hoc t-tests revealed decreased BOLD-signal in the right amygdala and left parahippocampal gyrus in both pharmacological conditions, compared to placebo. Escitalopram, compared to citalopram, induced a decrease of BOLD-signal in the medial frontal gyrus and an increase in the right fusiform and left parahippocampal gyri. Drug effects were concentrated in brain regions with dense serotonergic projections. Both escitalopram and citalopram attenuated BOLD-signal in the amygdala and parahippocampal cortex to emotionally significant stimuli compared to control stimuli. We believe that reduced reactivity in the medial frontal gyrus found for escitalopram compared to citalopram administration might explain the response differences between study drugs as demonstrated in previous clinical trials. |
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Authors:
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Christian Windischberger; Rupert Lanzenberger; Alexander Holik; Christoph Spindelegger; Patrycja Stein; Ulrike Moser; Florian Gerstl; Martin Fink; Ewald Moser; Siegfried Kasper |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-10-13 |
Journal Detail:
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Title: NeuroImage Volume: 49 ISSN: 1095-9572 ISO Abbreviation: Neuroimage Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: United States |
Other Details:
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Languages: eng Pagination: 1161-70 Citation Subset: IM |
Affiliation:
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MR Center of Excellence, Center for Biomedical Engineering and Physics, Medical University of Vienna, Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / blood supply, drug effects*, physiology* Brain Mapping Cerebrovascular Circulation / drug effects Citalopram / administration & dosage, blood, pharmacology* Cross-Over Studies Double-Blind Method Emotions European Continental Ancestry Group Executive Function / drug effects, physiology Facial Expression Female Humans Magnetic Resonance Imaging Male Neuropsychological Tests Oxygen / blood Serotonin Uptake Inhibitors / administration & dosage, blood, pharmacology* Visual Perception / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Uptake Inhibitors; 59729-33-8/Citalopram; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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