Document Detail

Area postrema lesions block feeding induced by systemic injections of monosodium glutamate.
MedLine Citation:
PMID:  3685149     Owner:  NLM     Status:  MEDLINE    
Glutamate is an amino acid neurotransmitter capable of producing widespread receptor-mediated neuronal excitation. Recently we reported that high doses of monosodium glutamate (MSG) given systemically stimulate food intake in a dose-related fashion. Since glutamate does not cross the blood-brain barrier, it seems possible that feeding was stimulated by an action of glutamate on neurons within circumventricular organs (CVOs), areas of the brain in which the blood-brain barrier is deficient. In this experiment, we tested the hypothesis that systemic MSG stimulates feeding by an action on the area postrema (AP), a CVO in the caudal hindbrain. AP-lesioned rats (APLs) and sham-operated controls (shams) were injected with saline or MSG (2 and 6 g/kg, SC, one dose per week). Food intake was measured for 3 hr immediately following the injection. Shams increased their food intake significantly in response to both doses of MSG, but APLs did not. This result suggests that systemic glutamate may stimulate feeding by an action on the AP.
S Ritter; S L Stone
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Physiology & behavior     Volume:  41     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1987  
Date Detail:
Created Date:  1988-01-12     Completed Date:  1988-01-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-4     Citation Subset:  IM    
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520.
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MeSH Terms
Avoidance Learning / physiology
Cerebral Ventricles
Feeding Behavior / drug effects*,  physiology
Glutamates / adverse effects*
Rats, Inbred Strains
Rhombencephalon / physiology*
Sodium Glutamate / adverse effects*
Grant Support
Reg. No./Substance:
0/Glutamates; 142-47-2/Sodium Glutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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