| AreA controls nitrogen source utilisation during both growth programs of the dimorphic fungus Penicillium marneffei. | |
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MedLine Citation:
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PMID: 22208609 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The opportunistic pathogen Penicillium marneffei displays a temperature-dependent dimorphic switching program with saprophytic hyphal growth at 25 °C and yeast growth at 37 °C. The areA gene of P. marneffei has been isolated and found to be required for the utilisation of nonpreferred nitrogen sources during both growth programs of P. marneffei, albeit to differing degrees. Based on this functional characterisation and high degree of sequence conservation with other fungal GATA factors, P. marneffei areA represents an orthologue of Aspergillus nidulans areA and Neurospora crassa NIT2. Based on this study it is proposed that AreA is likely to contribute to the pathogenicity of P. marneffei by facilitating growth in the host environment and regulating the expression of potential virulence factors such as extracellular proteases. |
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Authors:
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Hayley E Bugeja; Michael J Hynes; Alex Andrianopoulos |
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Publication Detail:
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Type: Journal Article Date: 2011-11-07 |
Journal Detail:
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Title: Fungal biology Volume: 116 ISSN: 1878-6146 ISO Abbreviation: Fungal Biol Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101524465 Medline TA: Fungal Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 145-54 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 British Mycological Society. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Genetics, University of Melbourne, Victoria 3010, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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