Document Detail

Are women less susceptible to exercise-induced muscle damage?
MedLine Citation:
PMID:  11706288     Owner:  NLM     Status:  MEDLINE    
Investigations using animal models show that estrogen is related to enzyme release, specifically creatine kinase, from exercised skeletal muscle. In humans, women have lower resting blood creatine kinase levels than men and have an attenuated blood creatine kinase response after prolonged endurance exercise. These results have led to the common belief that women may be protected from exercise-induced muscle damage due to circulating estrogen. Studies using laboratory models to examine gender differences in exercise-induced muscle damage, however, have not consistently documented that women have an attenuated response compared with men. Furthermore, research on exercise responses in women with different circulating levels of estrogen has not found estrogen to be related to indicators of muscle damage. Recent studies, in fact, have reported that women may experience more muscle damage, based on indirect measures, than men. Although some data exist that women may have a faster recovery from exercise-induced muscle damage, these results are tentative at this time.
P M Clarkson; M J Hubal
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in clinical nutrition and metabolic care     Volume:  4     ISSN:  1363-1950     ISO Abbreviation:  Curr Opin Clin Nutr Metab Care     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-13     Completed Date:  2002-04-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9804399     Medline TA:  Curr Opin Clin Nutr Metab Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  527-31     Citation Subset:  IM    
Department of Exercise Science, University of Massachusetts, Amherst, Massachusetts 01003, USA.
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MeSH Terms
Creatine Kinase / blood,  metabolism*
Estrogens / blood,  physiology*
Exercise / physiology*
Models, Animal
Muscle, Skeletal / enzymology,  injuries*
Myositis / etiology,  metabolism
Physical Endurance / physiology
Running / physiology
Sex Factors
Reg. No./Substance:
0/Estrogens; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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