| Are we studying and treating schizophrenia correctly? | |
| | |
MedLine Citation:
|
PMID: 21645998 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
New findings are rapidly revealing an increasingly detailed image of neural- and molecular-level dysfunction in schizophrenia, distributed throughout interconnected cortico-striato-pallido-thalamic circuitry. Some disturbances appear to reflect failures of early brain maturation, that become codified into dysfunctional circuit properties, resulting in a substantial loss of, or failure to develop, both cells and/or appropriate connectivity across widely dispersed brain regions. These circuit disturbances are variable across individuals with schizophrenia, perhaps reflecting the interaction of multiple different risk genes and epigenetic events. Given these complex and variable hard-wired circuit disturbances, it is worth considering how new and emerging findings can be integrated into actionable treatment models. This paper suggests that future efforts towards developing more effective therapeutic approaches for the schizophrenias should diverge from prevailing models in genetics and molecular neuroscience, and focus instead on a more practical three-part treatment strategy: 1) systematic rehabilitative psychotherapies designed to engage healthy neural systems to compensate for and replace dysfunctional higher circuit elements, used in concert with 2) medications that specifically target cognitive mechanisms engaged by these rehabilitative psychotherapies, and 3) antipsychotic medications that target nodal or convergent circuit points within the limbic-motor interface, to constrain the scope and severity of psychotic exacerbations and thereby facilitate engagement in cognitive rehabilitation. The use of targeted cognitive rehabilitative psychotherapy plus synergistic medication has both common sense and time-tested efficacy with numerous other neuropsychiatric disorders. |
| | |
Authors:
|
Neal R Swerdlow |
Related Documents
:
|
21049778 - Where do eds remain challenged? record keeping and egress integrity. 16519388 - Detecting adverse events in thai hospitals using medical record reviews: agreement amon... 2715838 - Use of return-to-work medical clearance data for health surveillance. 18018438 - Medical histories of 61 aviation accident pilots with postmortem ssri antidepressant re... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-4 |
Journal Detail:
|
Title: Schizophrenia research Volume: - ISSN: 1573-2509 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier B.V. All rights reserved. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A broad cortical reserve accelerates response to cognitive enhancement therapy in early course schiz...
Next Document: Modern parameterization and explanation techniques in diagnostic decision support system: A case stu...