| Are we any closer to beating the biofilm: novel methods of biofilm control. | |
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MedLine Citation:
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PMID: 20717027 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: A multidisciplinary approach to the treatment and management of biofilms has resulted from the growing appreciation of the role that biofilms play in modern medicine. Conventional antimicrobial agents are generally ineffective against biofilms, and as a result novel laboratory-based and clinical strategies have emerged. The purpose of this review is to analyse the recent literature relating to novel treatment strategies targeting the growing spectrum of clinically relevant biofilms. RECENT FINDINGS: Microscopy and molecular techniques have provided greater insights into identifying the key bacterial and fungal biofilm pathogens. Knowledge of these microorganisms has provided a foundation for the development of specific molecules, often microbial derived, with antimicrobial and/or biofilm disruptive properties, augmenting conventional antibiotics treatments. The validity of some such rationally designed therapeutics has been explored in clinical trials. SUMMARY: Biofilms are inherently difficult to treat, and mechanical disruption is the mainstay of clinical management. With scientific progress in molecular microbiology, there is an abundance of newly discovered molecules and pathways, providing novel therapeutic and prophylactic targets. |
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Authors:
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Gordon Ramage; Shauna Culshaw; Brian Jones; Craig Williams |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in infectious diseases Volume: 23 ISSN: 1473-6527 ISO Abbreviation: Curr. Opin. Infect. Dis. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2011-04-18 Revised Date: 2012-01-31 |
Medline Journal Info:
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Nlm Unique ID: 8809878 Medline TA: Curr Opin Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 560-6 Citation Subset: IM |
Affiliation:
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Glasgow Dental School and Hospital, Faculty of Medicine, University of Glasgow, UK. g.ramage@dental.gla.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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pharmacology,
therapeutic use* Bacteria / drug effects*, growth & development Biofilms / drug effects, growth & development* Catheters / microbiology Device Removal Fungi / drug effects, physiology* Gastrointestinal Tract / microbiology Humans Mouth / microbiology Prostheses and Implants / microbiology Respiratory System / microbiology Urinary Tract / microbiology Wounds and Injuries / microbiology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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