Document Detail

Are thyroid peroxidase antibodies associated with cardiovascular disease risk in patients with subclinical hypothyroidism?
MedLine Citation:
PMID:  15853828     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Conflicting evidence has been reported about whether subclinical hypothyroidism (SCH) is associated with hyperlipidemia or cardiovascular disease. Thyroid peroxidase antibodies (TPOAb) are more common in persons with SCH. The purpose of this study was to evaluate whether the presence of (TPOAb) in people with SCH is associated with markers of cardiovascular disease. DESIGN: Cross-sectional study using multivariate regression. PATIENTS: Adults over age 40 who, in the National Health and Nutrition Examination Survey (NHANES) III, met the criteria for SCH (n = 188). MEASUREMENTS: Participants were stratified into TPOAb-negative (n = 82) and TPOAb-positive (n = 106) groups. Markers of cardiovascular disease risk were compared between the TPOAb-negative and TPOAb-positive groups. Multivariate regression models were performed to adjust for potential confounders. RESULTS: In bivariate analyses, individuals with and without TPOAb had similar levels of triglycerides, high-density lipoprotein, low-density lipoprotein, total cholesterol and C-reactive protein. Homocysteine levels were higher in the patients without antibodies (P = 0.01). After adjusting for, age, gender, smoking, hypertension, diabetes and use of a lipid-lowering medication, however, no statistically significant relationships were found between the presence of TPOAb and any of the cardiovascular risk markers. CONCLUSIONS: The presence of thyroid peroxidase antibodies does not appear to correlate with cardiovascular disease risk in patients with subclinical hypothyroidism. This study does not support the measurement of TPOAb antibodies in SCH as a strategy for guiding treatment or assessment of cardiovascular disease risk.
Brian J Wells; William J Hueston
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical endocrinology     Volume:  62     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-04-27     Completed Date:  2005-07-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  580-4     Citation Subset:  IM    
Department of Family Medicine at the Cleveland Clinic Foundation, Strongsville, Ohio, USA.
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MeSH Terms
Autoantibodies / blood*
Biological Markers / analysis
C-Reactive Protein / analysis
Cardiovascular Diseases / immunology*
Cholesterol / blood
Epidemiologic Methods
Hypothyroidism / blood*
Iodide Peroxidase / immunology
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Middle Aged
Thyroglobulin / analysis
Thyroid Function Tests
Thyrotropin / blood
Thyroxine / blood
Triglycerides / blood
Grant Support
1 D14 HS 0016103/HS/AHRQ HHS
Reg. No./Substance:
0/Autoantibodies; 0/Biological Markers; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/thyroid microsomal antibodies; 57-88-5/Cholesterol; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin; 9007-41-4/C-Reactive Protein; 9010-34-8/Thyroglobulin; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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