| Are there potential problems with generic substitution of antiepileptic drugs? A review of issues. | |
| | |
MedLine Citation:
|
PMID: 16504545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In response to increasing cost pressures, healthcare systems are encouraging the use of generic medicines. This review explores potential problems with generic substitution of antiepileptic drugs (AEDs). A broad search strategy identified approximately 70 relevant articles. Potential problems with generic substitution included: The limited evidence (mainly case reports with some pharmacokinetic studies) appears to support these concerns for older AEDs. As a result, restrictions on use of specific generic AEDs are in place in some countries and recommended by some lay epilepsy organisations. As more AEDs lose patent protection, it is important to examine the question of whether generic substitution may pose problems for patients with epilepsy, and whether there should be safeguards to ensure that both physician and patient are informed when generic substitution occurs. |
| | |
Authors:
|
P Crawford; M Feely; A Guberman; G Kramer |
Related Documents
:
|
16469915 - The molecular basis for wine grape quality--a volatile subject. 11818355 - General practice-specific care categories: a method to examine the impact of morbidity ... 1625535 - James mchenry, m.d. of fort mchenry in baltimore towne. 17677685 - Choreographic solution to the general-relativistic three-body problem. 15035025 - Sars--beginning to understand a new virus. 11485225 - Assessment of groundwater quality impacts due to use of coal combustion byproducts to c... |
Publication Detail:
|
Type: Journal Article; Review Date: 2006-02-28 |
Journal Detail:
|
Title: Seizure : the journal of the British Epilepsy Association Volume: 15 ISSN: 1059-1311 ISO Abbreviation: Seizure Publication Date: 2006 Apr |
Date Detail:
|
Created Date: 2006-03-21 Completed Date: 2006-05-18 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9306979 Medline TA: Seizure Country: England |
Other Details:
|
Languages: eng Pagination: 165-76 Citation Subset: IM |
Affiliation:
|
York Hospital, Wigginton Road, York YO31 8HE, UK. pamela.crawford@york.nhs.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anticonvulsants*
/
economics,
pharmacokinetics,
therapeutic use Drugs, Generic* / economics, pharmacokinetics, therapeutic use Epilepsy / drug therapy*, economics Humans Therapeutic Equivalency |
| Chemical | |
Reg. No./Substance:
|
0/Anticonvulsants; 0/Drugs, Generic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bayesian mixed models and the phylogeny of pitvipers (Viperidae: Serpentes).
Next Document: Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tom...