Document Detail

Are there multiple proteolytic pathways contributing to c-Fos, c-Jun and p53 protein degradation in vivo?
MedLine Citation:
PMID:  10363646     Owner:  NLM     Status:  MEDLINE    
The c-Fos and c-Jun oncoproteins and the p53 tumor suppressor protein are short-lived transcription factors. Several catabolic pathways contribute to their degradation in vivo. c-Fos and c-Jun are thus mostly degraded by the proteasome, but there is indirect evidence that, under certain experimental/physiological conditions, calpains participate in their destruction, at least to a limited extent. Lysosomes have also been reported to participate in the destruction of c-Fos. Along the same lines, p53 is mostly degraded following the ubiquitin/proteasome pathway and calpains also seem to participate in its degradation. Moreover, c-Fos, c-Jun and p53 turnovers are regulated upon activation of intracellular signalling cascades. All taken together, these observations underline the complexity of the mechanisms responsible for the selective destruction of proteins within cells.
C Salvat; C Aquaviva; I Jariel-Encontre; P Ferrara; M Pariat; A M Steff; S Carillo; M Piechaczyk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular biology reports     Volume:  26     ISSN:  0301-4851     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-09-14     Completed Date:  1999-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Institut de Génétique Moléculaire, UMR5535 - CNRS, Montpellier, France.
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MeSH Terms
Cell Cycle
Cysteine Endopeptidases / metabolism
Multienzyme Complexes / metabolism
Proteasome Endopeptidase Complex
Proto-Oncogene Proteins c-fos / metabolism*
Proto-Oncogene Proteins c-jun / metabolism*
Signal Transduction
Tumor Suppressor Protein p53 / metabolism*
Reg. No./Substance:
0/Multienzyme Complexes; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-jun; 0/Tumor Suppressor Protein p53; EC 3.4.22.-/Cysteine Endopeptidases; EC Endopeptidase Complex

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