Document Detail


Are there interactions between S2-serotonergic and alpha 1-adrenergic receptors in isolated canine arteries?
MedLine Citation:
PMID:  2459508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experiments were performed to examine the interaction(s) between alpha 1-adrenergic and S2-serotonergic receptors of vascular smooth muscle of the dog. Rings of isolated coronary and femoral arteries (without endothelium) were suspended for isometric tension recording in organ chambers filled with modified Krebs-Ringer bicarbonate solution. 5-Hydroxytryptamine (serotonin) augmented the responsiveness to norepinephrine in the coronary artery (log shift at ED50 of the concentration-response curve: 2.9-fold). In the femoral artery, the contractions to either norepinephrine or the partial alpha 1-adrenergic agonist St 587 were unchanged by serotonin. Ketanserin (10(-9) M) augmented the response to the full alpha 1-adrenergic agonist phenylephrine, but not to that of St 587; at 5 x 10(-9) M, it depressed the contractions to phenylephrine. Ketanserin did not affect the alpha 1-adrenergic blocking properties of prazosin. By contrast, prazosin, in a concentration selective for alpha 1-adrenergic receptors, potentiated the inhibitory effect of ketanserin on contractions evoked by serotonin. These experiments suggest different interactions between S2-serotonergic and alpha 1-adrenergic receptors in the canine coronary and femoral artery.
Authors:
T F Lüscher; P M Vanhoutte
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  11 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-11-17     Completed Date:  1988-11-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S16-21     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Descriptor/Qualifier:
Animals
Coronary Vessels / drug effects,  physiology
Dogs
Female
Femoral Artery / drug effects,  physiology
Ketanserin / pharmacology
Male
Muscle Contraction* / drug effects
Muscle, Smooth, Vascular / drug effects,  physiology*
Norepinephrine / pharmacology
Phenylephrine / pharmacology
Prazosin / pharmacology
Receptors, Adrenergic, alpha / physiology*
Receptors, Serotonin / physiology*
Serotonin / pharmacology
Grant Support
ID/Acronym/Agency:
HL 05883/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 0/Receptors, Serotonin; 19216-56-9/Prazosin; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 59-42-7/Phenylephrine; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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