Document Detail

Are there errors in glycogen biosynthesis and is laforin a repair enzyme?
MedLine Citation:
PMID:  21930129     Owner:  NLM     Status:  Publisher    
Glycogen, a branched polymer of glucose, is well known as a cellular reserve of metabolic energy and/or biosynthetic precursors. Besides glucose, however, glycogen contains small amounts of covalent phosphate, present as C2 and C3 phosphomonoesters. Current evidence suggests that the phosphate is introduced by the biosynthetic enzyme glycogen synthase as a rare alternative to its normal catalytic addition of glucose units. The phosphate can be removed by the laforin phosphatase, whose mutation causes a fatal myoclonus epilepsy called Lafora disease. The hypothesis is that glycogen phosphorylation can be considered a catalytic error and laforin a repair enzyme.
Peter J Roach
Related Documents :
21728989 - Characterization of nuclear glutamate dehydrogenase of chicken liver and brain.
21434689 - Isolation of cholinesterase inhibiting flavonoids from morus lhou
21682139 - Isolation of a laccase with hiv-1 reverse transcriptase inhibitory activity from fresh ...
23028019 - Phylogeny and structure of the cinnamyl alcohol dehydrogenase gene family in brachypodi...
21880359 - Enzymatic activities in spermatozoa and butyltin concentrations in baltic turbot (scoph...
25369 - An affinity-column procedure for the purification of veratrate o-demethylase from fungi.
18045419 - The effect of nadp-dependent malic enzyme expression and anaerobic c4 metabolism in esc...
8633869 - Xylulose and glucose fermentation by saccharomyces cerevisiae in chemostat culture.
7950369 - Assay, purification, and properties of bovine liver d-xylulokinase.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-16
Journal Detail:
Title:  FEBS letters     Volume:  -     ISSN:  1873-3468     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilizati...
Next Document:  Influences of biological variables and geographic location on circulating concentrations of thyroid ...