Document Detail

Are there differences of inflammatory bio-markers between diabetic and non-diabetic patients with critical limb ischemia?
MedLine Citation:
PMID:  17164743     Owner:  NLM     Status:  MEDLINE    
AIM: This observational study was undertaken in order to analyse whether any differences could be detected between diabetic and non-diabetic patients with critical limb ischemia (CLI) concerning the inflammatory response. METHODS: A total number of 259 consecutive patients with CLI were treated between October 2001 and January 2003. RESULTS: Among the 259 patients, 135 (52%) had diabetes, previously known in 123, and detected during hospitalization in 12. The diabetic patients more often showed gangrene (P<0.05) and infra-inguinal atherosclerosis (84% vs 67%, P=0.001). The patients with diabetes showed a better lipid profile (total cholesterol 4.6 vs 5 mmol/L, P=0.006 and lower LDL-cholesterol (2.7 vs 3.1 mmol/L, P=0.010) despite the same frequency of statin treatment. They showed a higher creatinine (149 vs 117 micromol/L, P=0.0003) than the non-diabetic patients. Of the inflammatory markers, C-reactive protein (CRP) was equally elevated in both groups. Tumor necrosis factor-a (TNF-a) was increased among the diabetic patients (2.6 vs 1.8 pg/mL, P<0.05), and this difference was most evident in those with gangrene. Neopterin was also higher among the diabetic patients (31 vs 21 mmol/L, P<0.01), but CD40L was not different between groups. CONCLUSIONS: Diabetes mellitus was very common in CLI patients, and more often combined with renal impairment and infra-inguinal atherosclerosis. The inflammatory markers TNF-a and neopterin were elevated in patients with diabetes as compared to non-diabetic patients, but this difference cannot explain why CLI is 10 times more frequent in diabetic patients.
L Bertz; J Barani; A Gottsäter; P M Nilsson; I Mattiasson; B Lindblad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  25     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-13     Completed Date:  2007-06-21     Revised Date:  2008-07-17    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  370-7     Citation Subset:  IM    
Department of Vascular Diseases Malmö-Lund, Lund University, Malmö University Hospital, Malmö, Sweden.
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MeSH Terms
Biological Markers / blood
C-Reactive Protein / analysis*
Critical Illness
Diabetic Angiopathies / blood*
Inflammation / blood
Interferon-alpha / blood*
Interleukin-6 / blood*
Ischemia / blood*
Leg / blood supply*
Reg. No./Substance:
0/Biological Markers; 0/Interferon-alpha; 0/Interleukin-6; 9007-41-4/C-Reactive Protein
Comment In:
Int Angiol. 2008 Jun;27(3):269   [PMID:  18506132 ]

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