Document Detail

Are symptoms of peripheral neuropathy more prevalent in patients with Gaucher disease?
MedLine Citation:
PMID:  17376127     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A previous epidemiological survey from an American referral clinic noted a high incidence of neurological symptoms among patients with type I (non-neuronopathic) Gaucher disease all of whom were treated with specific enzyme replacement. OBJECTIVES: The current study replicates the above in a larger cohort of Ashkenazi Jewish patients with at least one N370S mutation which has been assumed to be protective of neurological involvement. About half the patients had mild disease and were untreated. Methods - Self-reporting questionnaires were sent to patients and their significant others as socio-economically matched controls. RESULTS: There was no significant difference between groups in incidence of concomitant diseases and medications, except patients who reported a significantly higher incidence of vitamin B(12) deficiency and gammopathies. Patients reported significantly higher incidence of virtually all symptoms and signs of peripheral neuropathy and a significantly higher number of symptoms than controls (mean 4.4 vs 2.4). CONCLUSIONS: The conclusion of this study, as of the seminal study, is that the high incidence of neurological complaints in patients with the non-neuronopathic form of Gaucher disease should be viewed in the context of concomitant illnesses, specifically, vitamin B(12) deficiency and gammopathies, regardless of the need for enzyme replacement therapy.
A Halperin; D Elstein; A Zimran
Related Documents :
1579877 - Metastatic adenocarcinoma of the spine.
2728877 - Adolescent lumbar disc prolapse.
8191877 - Sequelae one year after meningococcal disease.
16900087 - Nephronophthisis type 1 deletion syndrome with neurological symptoms: prevalence and si...
22990357 - Elevated troponin predicts long-term adverse cardiovascular outcomes in hypertensive cr...
21181017 - Pulmonary paracoccidioidomycosis: radiology and clinical-epidemiological evaluation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  115     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-22     Completed Date:  2007-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  275-8     Citation Subset:  IM    
Gaucher Clinic, Shaare Zedek Medical Center, Jerusalem, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Case-Control Studies
Gaucher Disease / complications*
Jews / statistics & numerical data*
Middle Aged
Peripheral Nervous System Diseases / complications*,  ethnology*
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low-dose subcutaneous injection of botulinum toxin type A for facial synkinesis and hyperlacrimation...
Next Document:  A clinical and immunological study of a myasthenia gravis patient treated with infliximab.