| Are sugars-free medicines more erosive than sugars-containing medicines? An in vitro study of paediatric medicines with prolonged oral clearance used regularly and long-term by children. | |
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MedLine Citation:
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PMID: 17559449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The reduced use of sugars-containing (SC) liquid medicines has increased the use of other dose forms, potentially resulting in more widespread dental effects, including tooth wear. The aim of this study was to assess the erosive potential of 97 paediatric medicines in vitro. METHODS: The study took the form of in vitro measurement of endogenous pH and titratable acidity (mmol). Endogenous pH was measured using a pH meter, followed by titration to pH 7.0 with 0.1-M NaOH. RESULTS: Overall, 55 (57%) formulations had an endogenous pH of < 5.5. The mean (+/- SD) endogenous pH and titratable acidity for 41 SC formulations were 5.26 +/- 1.30 and 0.139 +/- 0.133 mmol, respectively; for 56 sugars-free (SF) formulations, these figures were 5.73 +/- 1.53 and 0.413 +/- 1.50 mmol (P > 0.05). Compared with their SC bioequivalents, eight SF medicines showed no significant differences for pH or titratable acidity, while 15 higher-strength medicines showed lower pH (P = 0.035) and greater titratable acidity (P = 0.016) than their lower-strength equivalents. Chewable and dispersible tablets (P < 0.001), gastrointestinal medicines (P = 0.002) and antibiotics (P = 0.007) were significant predictors of higher pH. In contrast, effervescent tablets (P < 0.001), and nutrition and blood preparations (P = 0.021) were significant predictors of higher titratable acidity. CONCLUSIONS: Paediatric SF medicines were not more erosive than SC medicines in vitro; a more significant predictor of their erosive potential was dose form. |
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Authors:
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Anne Maguire; Wasim Baqir; June Heather Nunn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children Volume: 17 ISSN: 0960-7439 ISO Abbreviation: Int J Paediatr Dent Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-11 Completed Date: 2007-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107511 Medline TA: Int J Paediatr Dent Country: England |
Other Details:
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Languages: eng Pagination: 231-8 Citation Subset: D |
Affiliation:
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School of Dental Sciences, University of Newcastle, Newcastle upon Tyne, UK. A.Maguire@ncl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Child Child, Preschool Humans Hydrogen-Ion Concentration Metabolic Clearance Rate Mouth / metabolism Pharmaceutical Preparations / adverse effects*, chemistry* Sucrose / adverse effects Sweetening Agents / adverse effects* Titrimetry Tooth Erosion / chemically induced* Vehicles / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Pharmaceutical Preparations; 0/Sweetening Agents; 0/Vehicles; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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