| Are statins an option in the management of abdominal aortic aneurysms? | |
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MedLine Citation:
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PMID: 18421030 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Medline was searched for studies investigating the perioperative and long-term results that derive from statin use in patients with abdominal aortic aneurysm and the clinical and experimental evidence dealing with aneurysm expansion. Data suggest that statins improve the perioperative and long-term outcomes of aneurysm operations and may also reduce expansion rates. International guidelines recommend the use of statins in these patients because abdominal aortic aneurysms are considered as a coronary heart disease equivalent. These guidelines do not appear to have been widely implemented. Preliminary results suggest that statins might play a role in the management of abdominal aortic aneurysms. Verification of these results in large-scale trials may hold implications for a more comprehensive approach of patients with abdominal aortic aneurysms as well as population-wide aneurysm screening programs. Irrespective of the role of statins on aneurysm expansion rates, it is important to ensure that all abdominal aortic aneurysm patients receive statin therapy to improve perioperative and long-term morbidity and mortality. |
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Authors:
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Kosmas I Paraskevas; Christos D Liapis; George Hamilton; Dimitri P Mikhailidis |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Vascular and endovascular surgery Volume: 42 ISSN: 1538-5744 ISO Abbreviation: Vasc Endovascular Surg Publication Date: 2008 Apr-May |
Date Detail:
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Created Date: 2008-04-18 Completed Date: 2008-08-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136421 Medline TA: Vasc Endovascular Surg Country: United States |
Other Details:
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Languages: eng Pagination: 128-34 Citation Subset: IM |
Affiliation:
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Department of Clinical Biochemistry, Vascular Disease Prevention Clinic, Royal Free Hospital, Royal Free University College Medical School, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aortic Aneurysm, Abdominal / drug therapy*, mortality, pathology, surgery Cost-Benefit Analysis Drug Costs Evidence-Based Medicine Female Guideline Adherence Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / economics, therapeutic use* Male Mass Screening / methods Mice Patient Selection Practice Guidelines as Topic Rats Time Factors Treatment Outcome Vascular Surgical Procedures* / adverse effects |
| Chemical | |
Reg. No./Substance:
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0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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