| Are serum nitric oxide and vascular endothelial growth factor levels affected by packed red blood cell transfusions? | |
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MedLine Citation:
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PMID: 20557677 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nitric oxide (NO) and vascular endothelial growth factor (VEGF) are important mediators for hemodynamics and angiogenesis in the body. NO coming from endothelial cells and red blood cells is particularly effective in hypoxic vasodilation. VEGF has known effects on the induction of NO synthesis and is also known to be affected by blood product transfusions. The objectives of this study were to measure NO and VEGF levels before and after packed red blood cell (PRBC) transfusions. STUDY DESIGN AND METHODS: Blood was drawn from preterm newborns before and 30 min after PRBC transfusions and samples were used for NO and VEGF measurements. NO end products nitrite and nitrate were measured by modified Greiss method, VEGF levels measured by double sandwitch ELISA method. Vital signs including heart rate and blood pressure were also recorded. RESULTS: Thirty four newborns were included in the study and overall 54 transfusion episodes were assessed for mediator levels. No difference was observed between the mediator levels before and after PRBC transfusions. Vital signs were also unchanged. CONCLUSION: As there was no change in NO end product levels with PRBC transfusions, it might suggest that hypoxia was not severe enough to cause nitrite increase; however, other NO sources might still be active. VEGF levels were found to be unchanged and may reflect a delayed effect of transfusion on VEGF induction. |
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Authors:
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Ebru Ergenekon; Davut Bozkaya; Tayfun Goktas; Deniz Erbas; Aysegul Yucel; Ozden Turan; Ibrahim Hirfanoglu; Esra Onal; Canan Turkyilmaz; Esin Koc; Yildiz Atalay |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hematology (Amsterdam, Netherlands) Volume: 15 ISSN: 1607-8454 ISO Abbreviation: Hematology Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708388 Medline TA: Hematology Country: England |
Other Details:
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Languages: eng Pagination: 170-3 Citation Subset: IM |
Affiliation:
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Division of Newborn Medicine, Department of Pediatrics, Gazi University Hospital, Ankara, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anoxia
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blood Erythrocyte Transfusion* Humans Infant, Newborn / blood* Infant, Premature / blood* Nitric Oxide / blood*, metabolism Vascular Endothelial Growth Factor A / blood* Vital Signs |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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