| Are routine ancillary stains required to diagnose Helicobacter infection in gastric biopsy specimens? An institutional quality assurance review. | |
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MedLine Citation:
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PMID: 22261451 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastric biopsies are often done to evaluate for Helicobacter gastritis. Given the oncogenic association with Helicobacter gastritis and the relative ease of therapy, it is important for pathology departments to identify all positive cases. We describe an institutional quality assurance study of an institutional method for the diagnosis of Helicobacter gastritis. We reviewed 356 gastric biopsy specimens from a 4-week period at 1 institution. Approximately half were evaluated by 4 methods, H&E stain, Giemsa stain, Warthin-Starry stain, and Helicobacter immunostain, while the remainder were stained only with H&E and Helicobacter immunostains. There were 30 cases of Helicobacter gastritis diagnosed; about 83% of cases were diagnosed on the initial H&E-stained slides. Our study highlights a quality assurance study and a head-to head comparison of 4 methods not previously reported and supports the use of ancillary stains at the discretion of the sign-out pathologist. |
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Authors:
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Douglas J Hartman; Scott R Owens |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 137 ISSN: 1943-7722 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-20 Completed Date: 2012-03-06 Revised Date: 2012-03-22 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 255-60 Citation Subset: AIM; IM |
Affiliation:
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Dept of Pathology, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA. . |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Biopsy Female Gastric Mucosa / microbiology, pathology* Gastritis / diagnosis*, microbiology Helicobacter Infections / diagnosis*, microbiology Helicobacter pylori / isolation & purification Humans Male Middle Aged Quality Assurance, Health Care* Staining and Labeling / methods*, standards Young Adult |
| Comments/Corrections | |
Comment In:
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Am J Clin Pathol. 2012 Mar;137(3):343-5
[PMID:
22338045
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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