Document Detail

Are retinal microvascular caliber changes associated with severity of coronary artery disease in symptomatic cardiac patients?
MedLine Citation:
PMID:  19023691     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Recent population-based studies have shown that retinal vascular caliber may predict the risk of clinical coronary artery disease (CAD) events. Whether this association is related to macro- or microvascular mechanisms remains unknown. We investigated the relationship of retinal vascular caliber with severity and extent of CAD in symptomatic cardiac patients. MATERIALS AND METHODS: Overall, 98 patients attending diagnostic coronary angiography were recruited. Coronary angiography was used to assess for the severity and extent of CAD. Digital retinal photography was performed immediately prior to cardiac catheterization, and retinal vascular caliber was measured from these photographs by using a computer program and summarized as central retinal arteriolar (CRAE) and venular (CRVE) equivalents. RESULTS: Retinal arteriolar and venular calibers were not associated with increasing severity of CAD, as assessed by Leaman scores (CRAE/CRVE: P for trend=0.17/0.57), presence of clinically significant CAD (CRAE/CRVE: P=0.35/0.32), or number of diseased vessels (CRAE/CRVE: P for trend=0.18/0.69). CONCLUSIONS: Retinal vascular caliber changes are not associated with the severity of obstructive CAD in symptomatic patients. These data suggest that the association of retinal vascular caliber with clinical CAD seen in epidemiological studies may not be applicable to clinical symptomatic patients and may be related to microvascular, rather than macrovascular, mechanisms.
Andreas Josef Kreis; Thanh Tan Nguyen; Jie Jin Wang; Sophie Rogers; Ali Al-Fiadh; Melanie Freeman; Tien Yin Wong; H M Omar Farouque
Publication Detail:
Type:  Journal Article     Date:  2008-12-27
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  16     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  IM    
Centre for Eye Research Australia, University of Melbourne, 145 Studley Road, Heidelberg, Victoria 3084, Australia.
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MeSH Terms
Coronary Angiography
Coronary Artery Disease / pathology*,  physiopathology*
Middle Aged
Retina / pathology*,  physiopathology*
Severity of Illness Index
Venules / pathology,  physiopathology

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