| Are proton pump inhibitors a new antidiabetic drug? A cross sectional study. | |
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MedLine Citation:
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PMID: 22174957 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIM: To investigate the effect of proton pump inhibitors (PPIs) on glycemic control (HbA1c) in type 2 diabetic patients. METHODS: A cross-sectional study of consecutive in-patients admitted to hospital in any department during the first semester of the year 2010 who had a recent HbA1c measurement. The study excluded those with a diagnosis of hyperglycemic decompensation, diabetic onset or pregnancy. It compared HbA1c levels of those taking PPIs and those not. RESULTS: A total of 97 patients were recruited. The average HbA1C level was 7.0% ± 1.2%. Overall PPI consumption was 55.7%. HbA1c was significantly lower in individuals who took PPIs: -0.6%, 95% CI: -0.12 to -0.83. People who used PPIs with some type of insulin therapy had a HbA1c reduction by -0.8%, 95% CI: -0.12 to -1.48. For the rest of subgroup analysis based on the antidiabetic drug used, PPI consumption always exhibited lower HbA1c levels. CONCLUSION: PPIs seems to be consistently associated with better glycemic control in type 2 diabetes. HbA1c reduction observed is similar to incretin-based therapies. |
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Authors:
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Diana Boj-Carceller; Pilar Bocos-Terraz; Miguel Moreno-Vernis; Alejandro Sanz-Paris; Pablo Trincado-Aznar; Ramón Albero-Gamboa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of diabetes Volume: 2 ISSN: 1948-9358 ISO Abbreviation: World J Diabetes Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101547524 Medline TA: World J Diabetes Country: China |
Other Details:
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Languages: eng Pagination: 217-20 Citation Subset: - |
Affiliation:
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Diana Boj-Carceller, Alejandro Sanz-Paris, Pablo Trincado- Aznar, Ramón Albero-Gamboa, Endocrinology and Nutrition Unit, Hospital Miguel Servet, 50009 Zaragoza, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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