Document Detail

Are prosthetic heart valve fibrin strands negligible? The associations and significance.
MedLine Citation:
PMID:  19524400     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Filamentous fibrin strands (FSs) attached to valve prostheses have been well described in patients undergoing transesophageal echocardiography, but the frequency and clinical significance of these strands remain poorly defined. The aims of this study were to determine the frequency of prosthetic valve strands and to assess their significance in relation to clinical cerebral ischemic events (CIEs) and anticoagulant status. METHODS: Three hundred consecutive patients with 421 prosthetic heart valves were evaluated for the presence of FSs (highly mobile, filamentous masses<1 mm thick). RESULTS: FSs were found in 139 patients (49%) and 147 prostheses (38%) in patients with left-sided prostheses, with a significant association between FSs, CIEs, and anticoagulant status (P<.001). A lower international normalized ratio (<2.5) had a positive association with the occurrence of CIEs. CONCLUSIONS: There is a significant association between FSs, CIEs, and patient's anticoagulant status; therefore, aggressive anticoagulation and close follow-up are recommended for these patients.
Majid Kiavar; Anita Sadeghpour; Hooman Bakhshandeh; Parisa Tayyebi; Hossein Ali Bassiri; Maryam Esmaeilzadeh; Majid Maleki; Feridoun Noohi
Publication Detail:
Type:  Journal Article     Date:  2009-06-12
Journal Detail:
Title:  Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography     Volume:  22     ISSN:  1097-6795     ISO Abbreviation:  J Am Soc Echocardiogr     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-03     Completed Date:  2009-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8801388     Medline TA:  J Am Soc Echocardiogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  890-4     Citation Subset:  IM    
Department of Cardiovascular Medicine, Rajaie Cardiovascular Medical and Research Center, Tehran, Iran.
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MeSH Terms
Fibrin / analysis
Heart Valve Diseases / epidemiology*,  ultrasonography
Heart Valve Prosthesis / utilization*
Iran / epidemiology
Middle Aged
Postoperative Complications / epidemiology*,  ultrasonography
Risk Assessment
Risk Factors
Thrombosis / epidemiology*,  ultrasonography
Young Adult
Reg. No./Substance:
Comment In:
J Am Soc Echocardiogr. 2009 Aug;22(8):895-8   [PMID:  19647157 ]

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