Document Detail

Are prodromes preictal events? A prospective PDA-based study.
MedLine Citation:
PMID:  21514896     Owner:  NLM     Status:  Publisher    
Up to 29% of patients with epilepsy report "prodromal" sensations more than 30minutes prior to seizures. We developed and implemented an objective methodology to prospectively assess the sensitivity and specificity of these subjective experiences using personal digital assistants (PDAs). The key property, in contrast to paper-based diaries, is the internal recording of the patient's entering time of prodromes and seizures. Of 500 patients with epilepsy interviewed, 31 claimed to sense prodromal symptoms at least 30minutes before seizure onset. Eleven of them agreed to participate in a 4-week study to objectively measure their prospective prediction performance. In 9 patients returning data, the majority of prodrome entries were not followed by seizures or were identified only retrospectively. Statistical analysis revealed that no patient could outperform a nonspecific random predictor when predicting seizures based on the occurrence of prodromes, and that the group performance matched precisely the expected result for a by-chance prediction. These results question the predictive value of "prodromes" and the specificity of their occurrence in the preictal period.
Thomas Maiwald; Julie Blumberg; Jens Timmer; Andreas Schulze-Bonhage
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-21
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  -     ISSN:  1525-5069     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Freiburg Center for Data Analysis and Modeling, Freiburg University, Freiburg, Germany; Systems Biology Department, Harvard Medical School, Boston MA, USA.
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