Document Detail

Are pregnancy-associated plasma protein-A (PAPP-A) and CA 125 measurements after IVF-ET possible predictors of early pregnancy wastage?
MedLine Citation:
PMID:  2481686     Owner:  NLM     Status:  MEDLINE    
Pregnancy-associated plasma protein-A (PAPP-A), a macromolecular glycoprotein of placental origin, was reported to be depressed in established ectopic pregnancies. CA 125 is a known marker for ovarian cancer found to be elevated during the first trimester of pregnancy and in women with pelvic inflammatory disease. The present study investigated the usefulness of these parameters to predict the outcome of pregnancy in asymptomatic patients with a positive pregnancy test after in-vitro fertilization and embryo transfer (IVF-ET). Blood samples (n = 159) were obtained at different periods of time post-ET from 39 women, 21 of whom experienced a normal pregnancy, 12 had an intrauterine abortion and six had an ectopic pregnancy. PAPP-A and CA 125 were measured by radioimmunoassays. From day 30 onwards in normal pregnancies, PAPP-A was significantly increased over non-pregnant controls. In the spontaneous abortion group, the levels of PAPP-A were significantly lower than in normal pregnancy but higher than in non-pregnant controls. In ectopic pregnancy, PAPP-A remained at the level of non-pregnant controls throughout the entire observation period. CA 125 was significantly increased in all types of pregnancy. However, in two cases of hyperstimulation followed by a normal pregnancy and in four cases of ectopic pregnancy with signs of peritoneal irritation (hydrosalpinx, ruptured ectopic or salpingitis) the levels of CA 125 were 15-50 times higher than in normal pregnancies.(ABSTRACT TRUNCATED AT 250 WORDS)
P Bischof; T M Mignot; L Cédard
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  4     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-02-09     Completed Date:  1990-02-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  843-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Geneva, Switzerland.
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MeSH Terms
Abortion, Spontaneous / blood,  diagnosis*
Antigens, Tumor-Associated, Carbohydrate / analysis*
Embryo Transfer*
Fertilization in Vitro*
Pregnancy Outcome
Pregnancy Proteins / analysis*
Pregnancy Trimester, First
Pregnancy, Ectopic / blood
Pregnancy-Associated Plasma Protein-A / analysis*
Reg. No./Substance:
0/Antigens, Tumor-Associated, Carbohydrate; 0/Pregnancy Proteins; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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