| Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China? | |
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MedLine Citation:
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PMID: 15770721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To identify whether the polymorphisms of the N-acetyltransferase (NAT) genes are susceptible to primary liver cancer (PLC) in Luoyang, a PLC low-incidence area of China. METHODS: The NAT1 and NAT2 genotypes of 96 PLC cases and 173 controls were determined by PCR-RFLP. Both interaction between NAT1 or NAT2 and environmental risk factors were analyzed based on case control study. RESULTS: Compared to the control group, the frequencies of alleles NAT1*3, NAT1*4, NAT1*10, NAT1*14B and alleles NAT2*4, NAT2*6, NAT2*7 in PLC group showed no statistically significant difference (chi(2) = 2.61 and 4.16, respectively, both P>0.05). The frequencies of NAT1 genotypes NAT1*3/*3, NAT1*3/*4, NAT1*3/*10, NAT1*3/*14B, NAT1*4/*4, NAT1*4/*10, NAT1*4/*14B, NAT1*10/*10, NAT1*10/*14B, and NAT2 genotypes NAT2*4/*4, NAT2*4/*6, NAT2*4/*7, NAT2*6/*6, NAT2*6/*7 and NAT2*7/*7 also had no statistically significant difference between the two groups (chi(2) = 11.86 and 2.94 respectively both, P>0.05). Neither the frequencies of rapid and slow NAT1 acetylators nor the frequencies of rapid and slow NAT2 acetylators were significantly different between the two groups (chi(2) = 0.598 and 0.44, respectively, both P>0.05). The interaction between NAT1*10 and occupational exposures was found significant with an odds ratio of 3.40 (chi(2) = 8.42, P = 0.004, OR 95%CI:1.03-11.22). But no interaction was found between NAT2 and any environmental risk factors. CONCLUSION: The polymorphisms of NAT1 and NAT2 are not susceptible to PLC in Luoyang. Allele NAT1*10 interacts with occupational exposures. |
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Authors:
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Xiu-Feng Zhang; Jian-Chao Bian; Xiao-Yan Zhang; Zhu-Mei Zhang; Feng Jiang; Qi-Min Wang; Qi-Jun Wang; Yan-Yan Cao; Bo-Ming Tang |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 11 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-16 Completed Date: 2005-04-19 Revised Date: 2010-09-08 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1457-62 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China. jcbian@shmu.edu.cn. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Arylamine N-Acetyltransferase / genetics* China Female Genetic Predisposition to Disease* Humans Isoenzymes Liver Neoplasms / genetics* Male Middle Aged Polymorphism, Genetic* |
| Chemical | |
Reg. No./Substance:
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0/Isoenzymes; EC 2.3.1.5/Arylamine N-Acetyltransferase; EC 2.3.1.5/N-acetyltransferase 1; EC 2.3.1.5/NAT2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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