Document Detail


Are polymorphisms of N-acetyltransferase genes susceptible to primary liver cancer in Luoyang, China?
MedLine Citation:
PMID:  15770721     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To identify whether the polymorphisms of the N-acetyltransferase (NAT) genes are susceptible to primary liver cancer (PLC) in Luoyang, a PLC low-incidence area of China. METHODS: The NAT1 and NAT2 genotypes of 96 PLC cases and 173 controls were determined by PCR-RFLP. Both interaction between NAT1 or NAT2 and environmental risk factors were analyzed based on case control study. RESULTS: Compared to the control group, the frequencies of alleles NAT1*3, NAT1*4, NAT1*10, NAT1*14B and alleles NAT2*4, NAT2*6, NAT2*7 in PLC group showed no statistically significant difference (chi(2) = 2.61 and 4.16, respectively, both P>0.05). The frequencies of NAT1 genotypes NAT1*3/*3, NAT1*3/*4, NAT1*3/*10, NAT1*3/*14B, NAT1*4/*4, NAT1*4/*10, NAT1*4/*14B, NAT1*10/*10, NAT1*10/*14B, and NAT2 genotypes NAT2*4/*4, NAT2*4/*6, NAT2*4/*7, NAT2*6/*6, NAT2*6/*7 and NAT2*7/*7 also had no statistically significant difference between the two groups (chi(2) = 11.86 and 2.94 respectively both, P>0.05). Neither the frequencies of rapid and slow NAT1 acetylators nor the frequencies of rapid and slow NAT2 acetylators were significantly different between the two groups (chi(2) = 0.598 and 0.44, respectively, both P>0.05). The interaction between NAT1*10 and occupational exposures was found significant with an odds ratio of 3.40 (chi(2) = 8.42, P = 0.004, OR 95%CI:1.03-11.22). But no interaction was found between NAT2 and any environmental risk factors. CONCLUSION: The polymorphisms of NAT1 and NAT2 are not susceptible to PLC in Luoyang. Allele NAT1*10 interacts with occupational exposures.
Authors:
Xiu-Feng Zhang; Jian-Chao Bian; Xiao-Yan Zhang; Zhu-Mei Zhang; Feng Jiang; Qi-Min Wang; Qi-Jun Wang; Yan-Yan Cao; Bo-Ming Tang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  11     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-16     Completed Date:  2005-04-19     Revised Date:  2010-09-08    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1457-62     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China. jcbian@shmu.edu.cn.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Arylamine N-Acetyltransferase / genetics*
China
Female
Genetic Predisposition to Disease*
Humans
Isoenzymes
Liver Neoplasms / genetics*
Male
Middle Aged
Polymorphism, Genetic*
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.3.1.5/Arylamine N-Acetyltransferase; EC 2.3.1.5/N-acetyltransferase 1; EC 2.3.1.5/NAT2 protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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