| Are polyamines involved in the contractile effects of angiotensin II in the rat aorta? (Polyamines and angiotensin II in rat aorta). | |
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MedLine Citation:
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PMID: 15986523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin II (AII) is a central factor involved in the pathophysiology of arterial hypertension and atherosclerosis. On the other hand, polyamines represent a family of organic cations with low molecular weight, playing intracellular regulatory roles essential for the cellular growth and differentiation. The cellular contents, the synthesis and the transport of polyamines are increased following the actions of AII, as well as of other cellular growth factors. Our results show that the administration of polyamines as pre-treatment modulates the contractile effects of extracellular AII (80 nM). This modulation is concentration-dependent and dual: the lower concentrations amplify and the higher concentrations reduce the effects of AII in the isolated rat aorta rings without endothelium. Moreover, DL-alpha-Difluoromethylomithine (DFMO), a specific inhibitor of ornithine decarboxylase, does not significantly modify the contractile effects of AII. Thus, these data suggest that polyamines generated through this metabolic pathway are not involved in the contractile effects of AII in rat aortic vascular smooth muscle. |
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Authors:
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Natalia Costuleanu; Liliana Foia; Simona Mihaela Slătineanu; M Costuleanu; G Petrescu |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Romanian journal of physiology : physiological sciences / [Academia de Stiinte Medicale] Volume: 41 ISSN: 1223-4974 ISO Abbreviation: Rom J Physiol Publication Date: 2004 Jan-Jun |
Date Detail:
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Created Date: 2005-06-29 Completed Date: 2005-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9437433 Medline TA: Rom J Physiol Country: Romania |
Other Details:
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Languages: eng Pagination: 47-52 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Faculty of Dentistry, University of Medicine and Pharmacy Gr. T. Popa Iaşi, Romania. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology* Animals Aorta / drug effects*, physiology* Dose-Response Relationship, Drug Male Osmolar Concentration Polyamines / administration & dosage, metabolism*, pharmacology Rats Rats, Wistar Vasoconstriction / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Polyamines; 11128-99-7/Angiotensin II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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