| Are physiological effects of sleep deprivation in the rat mediated by bacterial invasion? | |
| | |
MedLine Citation:
|
PMID: 8899934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Recent reports have indicated that rats subjected to total sleep deprivation (TSD) by the disk-over-water method and sacrificed when death appeared imminent showed aerobic bacteria in their blood. Yoked control rats did not. Extrapolating from these results, it has been suggested that the late body temperature declines and eventual deaths of TSD rats are caused by septicemia, and that other, earlier-appearing effects of TSD-including weight loss, increased energy expenditure, and regulation of temperature at a higher level-might be mediated by impaired host defenses against bacterial invasion. Three measures of aerobic bacterial invasion were used to evaluate these hypotheses: bacteremia, bacterial colonization in major organs of filtration (liver, kidney, and mesenteric lymph nodes), and adherence of bacteria to the cecal wall. Experiment 1 showed nonsignificant trends toward more bacterial invasion in 4-day TSD rats compared to yoked control rats and no relationship between the bacterial indicators and the early TSD effects. Experiment 2 showed that the elimination of aerobic bacterial infection by antibiotic treatment did not prevent the early TSD effects in 4-day TSD rats. Experiment 3 showed that the elimination of aerobic bacterial invasion in TSD rats did not eliminate the late temperature decline or the progression towards death. The results showed no significant evidence of aerobic bacterial invasion early in TSD and no indication that the major effects of TSD were dependent upon aerobic bacterial invasion. |
| | |
Authors:
|
B M Bergmann; M A Gilliland; P F Feng; D R Russell; P Shaw; M Wright; A Rechtschaffen; J C Alverdy |
Related Documents
:
|
18597914 - Post-cardiac arrest temperature manipulation alters early eeg bursting in rats. 19868524 - Flagellum of the microorganism of rat-bite fever. 233774 - Tissue metabolism and enzyme activities in the rodent heterocephalus glaber, a poor tem... 2600044 - Changes in body temperature of rats acclimated to heat with different acclimation sched... 7384644 - The effects of the fumes from heated rosin (colophony) on tissue glutathione and xenobi... 1174524 - Different selectivities in acylation and methylation pathways of phosphatidylcholine fo... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Sleep Volume: 19 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 1996 Sep |
Date Detail:
|
Created Date: 1997-02-06 Completed Date: 1997-02-06 Revised Date: 2009-01-29 |
Medline Journal Info:
|
Nlm Unique ID: 7809084 Medline TA: Sleep Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 554-62 Citation Subset: IM |
Affiliation:
|
Department of Psychiatry, University of Chicago, Illinois, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Bacterial Agents / pharmacology, therapeutic use Bacteremia / complications*, drug therapy Male Rats Rats, Sprague-Dawley Sleep Deprivation* Sleep Disorders / etiology* Sleep, REM / drug effects |
| Grant Support | |
ID/Acronym/Agency:
|
MH-04151/MH/NIMH NIH HHS; MH-18428/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Bacterial Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin...
Next Document: Time course of reaction time and EEG while performing a vigilance task during total sleep deprivatio...