| Are patients with esophageal cancer who become PET negative after neoadjuvant chemoradiation free of cancer? | |
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MedLine Citation:
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PMID: 18471715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Esophageal cancer continues to increase in incidence. Many patients are presenting with stage II or greater disease and proceeding to neoadjuvant chemoradiation therapy before resection. Approximately 30% of patients will achieve a complete response and might not benefit from proceeding to resection. This study will examine the ability of PET to predict patients with a complete pathologic response. STUDY DESIGN: A query of our IRB-approved esophageal database revealed 81 patients who underwent a pre- and postchemoradiation PET scan and then proceeded to esophageal resection. Statistical analysis was performed to determine the ability of PET to predict a complete pathologic response. RESULTS: When comparing posttherapy PET with final pathology, it was determined that PET could not consistently differentiate a complete pathologic response from patients who still had persistent disease. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy were 61.8%, 43.8%, 70%, 35%, and 56%, respectively, for patients with a complete PET response after neoadjuvant therapy. CONCLUSIONS: A complete PET response after neoadjuvant chemoradiation is not substantially predictive of a complete pathologic response. Patients should still be referred for resection unless distant metastases are identified. |
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Authors:
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James M McLoughlin; Marcovalerio Melis; Erin M Siegel; E Michelle Dean; Jill M Weber; Jeannie Chern; Melanie Elliott; Scott T Kelley; Richard C Karl |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the American College of Surgeons Volume: 206 ISSN: 1879-1190 ISO Abbreviation: J. Am. Coll. Surg. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-12 Completed Date: 2008-05-29 Revised Date: 2009-05-21 |
Medline Journal Info:
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Nlm Unique ID: 9431305 Medline TA: J Am Coll Surg Country: United States |
Other Details:
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Languages: eng Pagination: 879-86; discussion 886-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Medical College of Georgia, Augusta, GA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Agents / administration & dosage* Esophageal Neoplasms / pathology, radionuclide imaging*, therapy* Female Humans Male Middle Aged Neoadjuvant Therapy Positron-Emission Tomography* Predictive Value of Tests Radiotherapy Remission Induction |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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