Document Detail


Are parkin patients particularly suited for deep-brain stimulation?
MedLine Citation:
PMID:  18228569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.
Authors:
Ebba Lohmann; Marie-Laure Welter; Valérie Fraix; Paul Krack; Suzanne Lesage; Sophie Laine; Marie-Laure Tanguy; Jean-Luc Houeto; Valérie Mesnage; Pierre Pollak; Alexandra Durr; Yves Agid; Alexis Brice;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  23     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-05-01     Completed Date:  2008-05-30     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  740-3     Citation Subset:  IM    
Copyright Information:
2008 Movement Disorder Society
Affiliation:
INSERM, U679, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antiparkinson Agents / adverse effects,  therapeutic use
DNA Mutational Analysis
Deep Brain Stimulation*
Dyskinesia, Drug-Induced
Female
Follow-Up Studies
Genetic Testing
Heterozygote
Homozygote
Humans
Levodopa / adverse effects,  therapeutic use
Male
Middle Aged
Mutation
Parkinsonian Disorders / genetics*,  therapy*
Treatment Outcome
Ubiquitin-Protein Ligases / genetics*
Grant Support
ID/Acronym/Agency:
NS41723-01A1/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; EC 6.3.2.19/Ubiquitin-Protein Ligases; EC 6.3.2.19/parkin protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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