Document Detail

Are papillary adenomas endolymphatic sac tumors?
MedLine Citation:
PMID:  7639470     Owner:  NLM     Status:  MEDLINE    
Papillary adenomas of the temporal bone have been considered as originating from the endolymphatic sac. The radiologic, surgical, and pathologic findings in a patient suffering from von Hippel-Lindau disease with bilateral papillary adenomas of the temporal bone cast some doubt on this site of origin. Radiologically, the center of tumor growth was at the top of the jugular bulb. Intraoperatively, the tumor was found to have reached the lateral wall of the endolymphatic sac, but the lumen was tumor-free. Both ciliated and nonciliated tumor cells were found in the resected tumor, resembling the ultrastructure of normal epithelial lining in the human mastoid. A strong positive immunohistochemical reaction for keratin and negative reactions for vimentin, glial fibrillary acidic protein, and S-100 protein in the tumor tissue of this patient are typical for middle ear mucosa. Therefore, the described papillary adenoma originated from the mucosa of the pneumatic spaces surrounding the jugular bulb, and the theory that the endolymphatic sac is the origin of all papillary-cystic tumors (adenocarcinomas) should be questioned.
A Pollak; A Böhmer; M Spycher; U Fisch
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  104     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-13     Completed Date:  1995-09-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  613-9     Citation Subset:  AIM; IM    
Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital, Zürich, Switzerland.
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MeSH Terms
Adenoma / complications,  pathology*,  surgery
Endolymphatic Sac*
Skull Neoplasms / complications,  pathology*,  surgery
Temporal Bone*
von Hippel-Lindau Disease / complications*
Comment In:
Ann Otol Rhinol Laryngol. 1996 Jan;105(1):83-4   [PMID:  8546433 ]
Ann Otol Rhinol Laryngol. 1996 Mar;105(3):251-2   [PMID:  8615592 ]

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