| Are paediatric medicines risk factors for dental caries and dental erosion? | |
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MedLine Citation:
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PMID: 20426261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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THE OBJECTIVE: To assess in vitro the cariogenic and erosive potentials of Brazilian liquid oral paediatric medicines. SETTING: Twenty-three paediatric medicines available on the Brazilian market were evaluated. The sample consisted of antihistamines, antitussives, bronchodilators and mucolytics. MAIN OUTCOME MEASURES: Duplicates of each bottle were analyzed for sugar concentration using normal-phase- high-performance liquid chromatography (HPLC). Quantification of sugars and sorbitol was calculated using the peak heights of commercial standards as references. pH measurements were determined using a digital pH meter. Titratable acidity was assessed by diluting three aliquots of each medicine, and increments of 0.1N NaOH were titrated until neutrality was reached. Viscosity was determined using a viscosemeter. RESULTS: Sugars were detected in 56.5% of the medicines. Sucrose was identified in 10 medicines, with concentrations ranging from 11.36 g% to 85.99 g%. Glucose was detected in five medicines, with concentrations varying from 4.64 g% to 40.19 g%; fructose in six medicines, with concentrations ranging from 5.09 g% to 46.71 g%. Twelve medicines exhibited sorbitol, with values ranging from 5.39 g% to 46.09 g%. Most tested medicines were acidic, with pH values ranging between 2.6 and 5.7. Only two medicines (Fluimucil and Polaramine) presented pH 6.4 and 6.0, respectively. Titratable acidity mean values ranged between 0.28 and 16.33 mL. Viscosity values varied between 2.8 cP and 412.3 cP. CONCLUSIONS: Many paediatric medicines showed high sugar concentration, pH values below the critical value and high titratable acidity values, all of which increase the medicines' cariogenic and erosive potentials. |
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Authors:
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B G Neves; A Farah; E Lucas; V P de Sousa; L C Maia |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Community dental health Volume: 27 ISSN: 0265-539X ISO Abbreviation: Community Dent Health Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-29 Completed Date: 2010-05-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8411261 Medline TA: Community Dent Health Country: England |
Other Details:
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Languages: eng Pagination: 46-51 Citation Subset: D; IM |
Affiliation:
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Departamento de Odontopediatria e Ortodontia, Universidade Federal do Rio de Janeiro, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brazil Cariogenic Agents Child Child, Preschool Chromatography, High Pressure Liquid Dental Caries / etiology* Drug Carriers / adverse effects* Fructose / adverse effects Glucose / adverse effects Humans Hydrogen-Ion Concentration Pharmaceutical Preparations / adverse effects*, chemistry Risk Factors Sucrose / adverse effects Sweetening Agents / adverse effects Tooth Erosion / etiology* Vehicles / adverse effects* Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Cariogenic Agents; 0/Drug Carriers; 0/Pharmaceutical Preparations; 0/Sweetening Agents; 0/Vehicles; 30237-26-4/Fructose; 50-99-7/Glucose; 57-50-1/Sucrose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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