Document Detail

Are overnight urinary indicators associated with morning blood pressure in the elderly?
MedLine Citation:
PMID:  18214730     Owner:  NLM     Status:  MEDLINE    
Recent reports suggest that high blood pressure (BP) during the night is associated with hypertensive organ damage, and that increased BP in the morning is closely related to the incidence of stroke and ischemic heart disease. The aim of this study was to investigate the relationships between overnight urinary indicators and 24-hour (24-h) BP, especially in the morning and during sleep in the elderly. A total of 85 volunteers (males 43, females 42), aged between 51 and 76 years and not taking any antihypertensive medications, participated in this study. Their 24-h BP was measured by ambulatory BP monitoring every 30-minute using a TERUMO ES-H531 system. Overnight urine samples were collected using a proportional urine-sampling device, Urine mate P. Overnight sodium (UNa(n)) and potassium (UKn) excretions were measured by an ion electrode method. Simple linear regression analyses showed that systolic blood pressure (SBP) in the morning and diastolic blood pressure (DBP) during sleep were negatively related with overnight urinary weight standardized for body weight (UW(n)/BW). Multiple regression analyses showed that SBP during the morning and during sleep was positively related to UNa(n) and negatively related to UW(n)/BW. We also found a negative relationship between SBP during sleep and UK(n). The study suggested that urine weight adjusted for BW was negatively related with 24-h BP, especially morning BP. Sodium excretion combined with a large volume of urine proportional to body weight may prevent increases in BP, especially in the morning.
K Yamasue; T Hayashi; K Ohshige; O Tochikubo; T Souma
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  30     ISSN:  1525-6006     ISO Abbreviation:  Clin. Exp. Hypertens.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Department of Preventive Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
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MeSH Terms
Biological Markers / urine
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology*
Geriatric Assessment
Middle Aged
Potassium / urine
Regression Analysis
Sleep / physiology*
Sodium / urine
Urine* / chemistry,  physiology
Reg. No./Substance:
0/Biological Markers; 7440-09-7/Potassium; 7440-23-5/Sodium

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