Document Detail

Are non-diabetic women with abnormal glucose screening test at increased risk of pre-eclampsia, macrosomia and caesarian birth?
MedLine Citation:
PMID:  8523639     Owner:  NLM     Status:  MEDLINE    
To determine, in non-diabetic women, the relationship of abnormal glucose screening test, with the incidence of pre-eclampsia, macrosomia and caesarian delivery, from 1988-92, 5646 consecutive women attending antenatal clinic were screened with a glucose challenge test (GCT) on their first visit (usually at 16-20 weeks); those with risk factors i.e., history of unexplained perinatal loss, macrosomia or family member with diabetes and an initial abnormal screening test were rescreened at 28-32 weeks. In 482 cases the GCT was abnormal (plasma glucose value was > 140 mg% 2 hours after 75 g glucose challenge). Of these, 292 had one or more abnormal critical values at a 75 g-3 hour oral glucose tolerance test (GTT) and they were treated to maintain euglycaemia. The rest (n = 190) had no evidence of glucose intolerance with no abnormal values at the GTT. The subjects were divided into 3 groups based on GCT values; A, randomly selected subjects with a normal GCT (n = 1000); B, those with abnormal GCT but normal GTT (n = 190); and C, those with abnormal GTT (n = 292). The variables studied were age, gravidity, parity, gestational age at delivery, pre-eclampsia, birth-weight and mode of delivery. The incidence of pre-eclampsia and caesarian birth varied, being the lowest in Group A (3.9% and 11.9% respectively) and then rising through group B (6.3% and 16.3% respectively) to the highest in Group C (12.6% and 26.0% respectively; test of linear trend, p < 0.05). For macrosomia, the incidence increased from Group A to B but there was a drop in Group C.(ABSTRACT TRUNCATED AT 250 WORDS)
K S Khan; F A Hashmi; J H Rizvi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  45     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-01-22     Completed Date:  1996-01-22     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  PAKISTAN    
Other Details:
Languages:  eng     Pagination:  176-9     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Aga Khan University Medical Centre, Karachi.
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MeSH Terms
Analysis of Variance
Cesarean Section*
Chi-Square Distribution
Fetal Macrosomia / blood,  prevention & control*
Glucose Tolerance Test / methods
Hyperglycemia / blood,  complications*
Linear Models
Pakistan / epidemiology
Pre-Eclampsia / blood,  prevention & control*
Pregnancy Complications* / blood,  prevention & control*
Sensitivity and Specificity

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