| Are non-diabetic women with abnormal glucose screening test at increased risk of pre-eclampsia, macrosomia and caesarian birth? | |
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MedLine Citation:
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PMID: 8523639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine, in non-diabetic women, the relationship of abnormal glucose screening test, with the incidence of pre-eclampsia, macrosomia and caesarian delivery, from 1988-92, 5646 consecutive women attending antenatal clinic were screened with a glucose challenge test (GCT) on their first visit (usually at 16-20 weeks); those with risk factors i.e., history of unexplained perinatal loss, macrosomia or family member with diabetes and an initial abnormal screening test were rescreened at 28-32 weeks. In 482 cases the GCT was abnormal (plasma glucose value was > 140 mg% 2 hours after 75 g glucose challenge). Of these, 292 had one or more abnormal critical values at a 75 g-3 hour oral glucose tolerance test (GTT) and they were treated to maintain euglycaemia. The rest (n = 190) had no evidence of glucose intolerance with no abnormal values at the GTT. The subjects were divided into 3 groups based on GCT values; A, randomly selected subjects with a normal GCT (n = 1000); B, those with abnormal GCT but normal GTT (n = 190); and C, those with abnormal GTT (n = 292). The variables studied were age, gravidity, parity, gestational age at delivery, pre-eclampsia, birth-weight and mode of delivery. The incidence of pre-eclampsia and caesarian birth varied, being the lowest in Group A (3.9% and 11.9% respectively) and then rising through group B (6.3% and 16.3% respectively) to the highest in Group C (12.6% and 26.0% respectively; test of linear trend, p < 0.05). For macrosomia, the incidence increased from Group A to B but there was a drop in Group C.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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K S Khan; F A Hashmi; J H Rizvi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JPMA. The Journal of the Pakistan Medical Association Volume: 45 ISSN: 0030-9982 ISO Abbreviation: J Pak Med Assoc Publication Date: 1995 Jul |
Date Detail:
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Created Date: 1996-01-22 Completed Date: 1996-01-22 Revised Date: 2008-02-12 |
Medline Journal Info:
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Nlm Unique ID: 7501162 Medline TA: J Pak Med Assoc Country: PAKISTAN |
Other Details:
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Languages: eng Pagination: 176-9 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynaecology, Aga Khan University Medical Centre, Karachi. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Cesarean Section* Chi-Square Distribution Female Fetal Macrosomia / blood, prevention & control* Glucose Tolerance Test / methods Humans Hyperglycemia / blood, complications* Linear Models Pakistan / epidemiology Pre-Eclampsia / blood, prevention & control* Pregnancy Pregnancy Complications* / blood, prevention & control* Sensitivity and Specificity |
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