Document Detail

Are new agents used to treat rheumatoid arthritis safe to take during pregnancy? Organization of Teratology Information Specialists (OTIS) study.
MedLine Citation:
PMID:  17872672     Owner:  NLM     Status:  MEDLINE    
QUESTION: I have a patient planning pregnancy who has resistant rheumatoid arthritis that will require treatment with some of the "new" medications. Which ones are safe to use during pregnancy, and which ones do we know enough about to tell whether they are safe or not?
ANSWER: For most new disease-modifying biologic medications, we have few data on safety. More and more reassuring data are accumulating on azathioprine and cyclosporine. When you treat this patient, you can help in gathering such data by contacting the Organization of Teratology Information Specialists' Autoimmune Disease in Pregnancy study through Motherisk at 877 311-8972.
Christina Chambers; Gideon Koren; Zuhre N Tutuncu; Diana Johnson; Kenneth L Jones
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian family physician Médecin de famille canadien     Volume:  53     ISSN:  1715-5258     ISO Abbreviation:  Can Fam Physician     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-10-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  0120300     Medline TA:  Can Fam Physician     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM    
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MeSH Terms
Abnormalities, Drug-Induced / diagnosis*,  epidemiology
Antimalarials / administration & dosage,  adverse effects
Antirheumatic Agents / administration & dosage,  adverse effects*
Arthritis, Rheumatoid / diagnosis,  drug therapy
Azathioprine / administration & dosage,  adverse effects
Information Services
Isoxazoles / administration & dosage,  adverse effects
Pregnancy Complications / drug therapy*
Pregnancy Outcome*
Pregnancy Trimester, First
Risk Assessment
Sulfasalazine / administration & dosage,  adverse effects
Reg. No./Substance:
0/Antimalarials; 0/Antirheumatic Agents; 0/Isoxazoles; 0/Teratogens; 446-86-6/Azathioprine; 599-79-1/Sulfasalazine; 75706-12-6/leflunomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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