Document Detail

Are the neuroprotective effects of estradiol and physical exercise comparable during ageing in female rats?
MedLine Citation:
PMID:  22722983     Owner:  NLM     Status:  MEDLINE    
Ageing of the brain is accompanied by variable degrees of cognitive decline. Estrogens have profound effects on brain ageing by exerting neurotrophic and neuroprotective types of action. Furthermore, exercise has also been claimed to play a role in the non-pharmacological prevention of psycho-neuronal decline with ageing. In the present study the question was asked whether chronic physical exercise might substitute the action of estrogens in aged rats. We compared the effects of 17β-estradiol (E2) treatment and long-term moderate physical exercise in ageing (15 months, early stage of ageing) and old (27 months) female rats, on cognitive functions and the relevant intracellular molecular signaling pathways in the hippocampus. Results showed that both treatments improved attention and memory functions of the 15 months old rats. Like E2, physical training enhanced the level of brain derived nerve growth factor and the activation of PKA/Akt/CREB and MAPK/CREB pathways. The treatments also enhanced the levels of synaptic molecules synaptophysin and synapsin I, which could explain the improved cognitive functions. In the 27 months old rats the behavioral and molecular effects of E2 were indistinguishable from those found in the 15 months old animals but the effects of physical exercise in most of the measures proved to be practically ineffective. It is concluded that the effectiveness of regular and moderate intensity physical exercise is age-dependent while the action of E2 treatment is comparable between the ageing and old female rats on maintaining cognition and its underlying molecular mechanisms.
Krisztina Marosi; Klára Felszeghy; Raj D Mehra; Zsolt Radák; Csaba Nyakas
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2012-06-22
Journal Detail:
Title:  Biogerontology     Volume:  13     ISSN:  1573-6768     ISO Abbreviation:  Biogerontology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2013-01-17     Revised Date:  2013-04-24    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  413-27     Citation Subset:  IM    
Research Institute of Sport Sciences, Semmelweis University, 1123 Alkotás u. 44, Budapest, Hungary.
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MeSH Terms
Aging / physiology*
Cognition / drug effects*,  physiology*
Estradiol / administration & dosage,  pharmacology*
Hippocampus / drug effects,  physiology
Injections, Subcutaneous
Memory / drug effects,  physiology
Models, Animal
Neuroprotective Agents*
Physical Conditioning, Animal / physiology*
Rats, Wistar
Signal Transduction / drug effects,  physiology
Treatment Outcome
Reg. No./Substance:
0/Neuroprotective Agents; 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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