Document Detail


Are myo-inositol, glucose and zinc concentrations in amniotic fluid of fetuses with spina bifida different from controls?
MedLine Citation:
PMID:  12614945     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Associations are reported between myo-inositol, glucose, zinc and the occurrence of spina bifida. To gain more insight into the pathogenesis of spina bifida, the concentrations of myo-inositol, glucose and zinc were determined in amniotic fluids from pregnancies with a spina bifida or unaffected control fetus. METHODS: Amniotic fluids of 27 pregnancies complicated by spina bifida and 49 controls were collected at the Department of Obstetrics and Gynecology of the University Medical Center Nijmegen in the Netherlands. Myo-inositol, glucose and zinc concentrations were determined. By indication, the samples were taken at different gestational ages. Therefore, the data were evaluated using multiple linear regression analysis to adjust for gestational age. RESULTS: Amniocentesis was performed at a more advanced gestational age in the spina bifida group than in controls. In the spina bifida group, amniotic fluid myo-inositol, glucose and zinc concentrations gradually declined throughout pregnancy. At a gestational age of 15 weeks, the estimated mean amniotic fluid glucose and zinc concentrations in the spina bifida group were, respectively, significantly lower (p< or =0.5) and higher (p< or =0.5) compared with the control group. At the same gestational age, the estimated mean myo-inositol concentrations were comparable in both groups. At a gestational age of 38 weeks, the estimated mean myo-inositol, glucose and zinc concentrations were not significantly different in the spina bifida compared with the control group. CONCLUSION: This study may suggest that a derangement in zinc and glucose transfer or metabolism is associated with spina bifida. Since compounds in amniotic fluid are only a very crude marker of the actual fetal condition, studies that focus on the metabolism of these compounds on tissue or even cellular level should be performed to clarify their role in the pathogenesis and future prevention of spina bifida.
Authors:
Pascal M W Groenen; Ron A Wevers; Fokje S M Janssen; Joep H A M Tuerlings; Johannes M W M Merkus; Régine P M Steegers-Theunissen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  71     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-04     Completed Date:  2003-10-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Department of Epidemiology and Biostatistics, University Medical Center Nijmegen, 6500 HB Nijmegen, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / chemistry,  metabolism*
Female
Gestational Age
Glucose / analysis,  metabolism*
Humans
Inositol / analysis,  metabolism*
Maternal Age
Pregnancy
Pregnancy, High-Risk
Spectrophotometry, Atomic
Spinal Dysraphism / etiology,  metabolism*
Zinc / analysis,  metabolism*
Chemical
Reg. No./Substance:
50-99-7/Glucose; 6917-35-7/Inositol; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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