| Are monoclonal gammopathies in rheumatoid arthritis predictive for lymphoproliferative disorders? | |
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MedLine Citation:
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PMID: 17041377 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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There is limited evidence for the association of specific malignancies with rheumatoid arthritis (RA). Monoclonal gammopathies can occur in RA. Their predictive value for the development of a lymphoproliferative disorder remains unclear and disputed. We reviewed charts of 214 RA patients all of whom had at least one serum protein electrophoresis. We performed a retrospective study of 12 patients with RA and an M spike. We further characterized the M spike by serum immunofixation and bone marrow studies. The median age at which the M spike was identified was 69 years. IgG was the predominant gammopathy in 50% of patients, with no difference in the amount of kappa (kappa) and lambda (lambda) chains. One patient was diagnosed with multiple myeloma, one with an undefined primary lymphoproliferative disorder, one with T-cell leukemia, five with myelodysplastic syndrome, and four with monoclonal gammopathy of undetermined significance at most recent evaluation. Of our patients, 42% had a myelodysplastic syndrome, which has not been previously reported, and, in contrast to previous reports, no lymphomas were identified. The follow-up evaluation of patients with myelodysplastic syndrome and monoclonal gammopathy of undetermined significance is important because they may progress to an overt neoplasia. |
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Authors:
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Luis A Toro-Jiménez; William Cáceres; Edwin Mejías |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases Volume: 8 ISSN: 1076-1608 ISO Abbreviation: J Clin Rheumatol Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2006-10-16 Completed Date: 2007-07-10 Revised Date: 2008-04-10 |
Medline Journal Info:
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Nlm Unique ID: 9518034 Medline TA: J Clin Rheumatol Country: United States |
Other Details:
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Languages: eng Pagination: 243-6 Citation Subset: - |
Affiliation:
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San Juan Veterans Affairs Medical Center, San Juan, Puerto Rico 00921, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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