Document Detail

Are maximum P wave duration and P wave dispersion a marker of target organ damage in the hypertensive population?
MedLine Citation:
PMID:  17938849     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: High blood pressure, left ventricular hypertrophy and diastolic dysfunction may cause hemodynamic and morphological changes in the left atrium, consequently instability and heterogeneity in atrial conduction. This is seen as an increase in maximum P wave duration (P(max)) and P wave dispersion (PD) on the electrocardiogram (ECG). P wave dispersion on ECG has been encountered as a risk factor for atrial fibrillation (AF). The aim of this study is to examine whether PD and P(max) can be used as a non-invasive marker of target organ damage (LVH and diastolic dysfunction) in a hypertensive population. MATERIAL AND METHODS: The study registered a total of 120 cases (mean age 46.9 +/- 10.6 years; 58 [48.3%] males and 62 [51.7%] females), of whom 60 were patients diagnosed as essential hypertension (group 1), and 60 were healthy individuals, who constituted the control group (group 2). Systolic and diastolic functions of all cases were evaluated by echocardiography, and maximum P wave duration (P(max)), and PD was calculated. RESULTS: Maximum P wave duration was 91.6 +/- 10.2 ms in group 1, and 64 +/- 10.2 ms in group 2 (p < 0.01), while PD was 56.1 +/- 5.8 ms in group 1, and 30.3 +/- 6.6 ms in group 2 (p < 0.01). Blood pressure, left atrium diameter, DT, IVRT, and E/A ratio, as well as left ventricular mass index increased markedly in group 1. CONCLUSION: High blood pressure, LVH, diastolic dysfunction and increased left atrium diameter and volume shows parallelism in hypertensive cases. These physiopathological changes may cause different and heterogeneous atrial electrical conduction. This led to a marked increase in P(max) and PD in our cases. Thus, the results support the hypothesis that PD can be used as a non-invasive marker of target organ damage (LVH and LV diastolic dysfunction) in the hypertension population.
Necati Dagli; Ilgin Karaca; Mustafa Yavuzkir; Mehmet Balin; Nadi Arslan
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-10-19
Journal Detail:
Title:  Clinical research in cardiology : official journal of the German Cardiac Society     Volume:  97     ISSN:  1861-0692     ISO Abbreviation:  Clin Res Cardiol     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-18     Completed Date:  2009-10-15     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  101264123     Medline TA:  Clin Res Cardiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  98-104     Citation Subset:  IM    
Firat Universitesi, Elazig, Turkey.
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MeSH Terms
Biological Markers
Blood Pressure Determination / methods
Case-Control Studies
Chi-Square Distribution
Disease Progression
Heart Failure, Systolic / diagnosis*,  etiology,  mortality
Hypertension / complications*,  diagnosis
Hypertrophy, Left Ventricular / diagnosis*,  etiology,  mortality
Middle Aged
Reference Values
Risk Assessment
Severity of Illness Index
Survival Analysis
Reg. No./Substance:
0/Biological Markers

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