Document Detail

Are mast cells MASTers in HIV-1 infection?
MedLine Citation:
PMID:  11435725     Owner:  NLM     Status:  MEDLINE    
HIV-1 gp120 interacts with IgE V(H)3(+) on the surface of human basophils and mast cells (Fc epsilon RI(+) cells), acting as a viral immunoglobulin superantigen. gp120 from different clades induces mediator release from Fc epsilon RI(+) cells. gp120 also induces IL-4 and IL-13 synthesis in human basophils. The chemokine receptors CCR3 and CXCR4, which are coreceptors of HIV-1 infection, are expressed by human Fc epsilon RI(+) cells. HIV-1 Tat protein is a potent chemoattractant for basophils and lung mast cells, interacting with CCR3. Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human Fc epsilon RI(+) cells could be infected in vitro by M-tropic HIV-1 strains.
G Marone; A de Paulis; G Florio; A Petraroli; F W Rossi; M Triggiani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International archives of allergy and immunology     Volume:  125     ISSN:  1018-2438     ISO Abbreviation:  Int. Arch. Allergy Immunol.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-03     Completed Date:  2001-08-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9211652     Medline TA:  Int Arch Allergy Immunol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy.
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MeSH Terms
Basophils / metabolism,  virology*
Gene Expression Regulation, Viral
Gene Products, tat / pharmacology,  physiology
HIV Envelope Protein gp120 / immunology,  physiology*
HIV Infections / immunology*,  virology
HIV-1 / immunology,  physiology*
Histamine Release
Immunoglobulin E / biosynthesis,  genetics
Interleukin-13 / biosynthesis
Interleukin-4 / biosynthesis
Macromolecular Substances
Mast Cells / metabolism,  virology*
Receptors, CCR3
Receptors, CXCR4 / biosynthesis,  genetics,  physiology
Receptors, Chemokine / biosynthesis,  genetics,  physiology*
Receptors, IgE / physiology*
Superantigens / immunology
Th1 Cells / immunology
Th2 Cells / immunology
Virus Replication
tat Gene Products, Human Immunodeficiency Virus
Reg. No./Substance:
0/CCR3 protein, human; 0/Gene Products, tat; 0/HIV Envelope Protein gp120; 0/Interleukin-13; 0/Macromolecular Substances; 0/Receptors, CCR3; 0/Receptors, CXCR4; 0/Receptors, Chemokine; 0/Receptors, IgE; 0/Superantigens; 0/tat Gene Products, Human Immunodeficiency Virus; 207137-56-2/Interleukin-4; 37341-29-0/Immunoglobulin E

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