Document Detail

Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation?
MedLine Citation:
PMID:  10328869     Owner:  NLM     Status:  MEDLINE    
In this study the authors assessed the sequential release of lipid mediators (TXB2, PGE2, 6-keto-PGF1alpha, LTB4, LTC4, PAF), pro-inflammatory cytokines (IL-6, IL-8, TNF-alpha) and anti-inflammatory cytokines (IL-4, IL-10) in 17 patients undergoing coronary artery bypass graft (CABG) with extracorporeal circulation (ECC). Time course of appearance of inflammatory mediators revealed the early and transient increase in lipid mediator plasma concentrations (6-keto-PGF1alpha, LTB4, LTC4, PAF) whereas cytokines (IL-6, IL-8, IL-10) were involved only in late pre- and post-operative periods. No variation of TXB2, PGE2, IL-4 and TNF-alpha levels were found. No correlation was documented between the levels of lipid mediators and pro- or anti-inflammatory cytokines suggesting that lipidic compounds are not implicated in the genesis of cytokines which appear much later involved. Despite the common use of high doses of aprotinin (a non-specific enzyme inhibitor) in hope to abrogate the inflammatory response to cardiopulmonary bypass procedure, this study reports the persistent release of several inflammatory compounds that might be involved in the post-CABG multiple organ failure syndromes.
Y Denizot; P Feiss; N Nathan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cytokine     Volume:  11     ISSN:  1043-4666     ISO Abbreviation:  Cytokine     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-06-21     Completed Date:  1999-06-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-4     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Laboratoire d'Hématologie Expérimentale, Faculté de Médecine, 2 rue Dr Marcland, Limoges, 87025, France.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / blood
Anti-Inflammatory Agents / blood
Cardiopulmonary Bypass / adverse effects*
Cytokines / biosynthesis*,  blood
Dinoprostone / blood
Extracorporeal Circulation / adverse effects*
Inflammation Mediators / blood
Interleukin-10 / blood
Interleukin-4 / blood
Interleukin-6 / blood
Interleukin-8 / blood
Leukotriene B4 / blood
Leukotriene C4 / blood
Lipid Metabolism*
Lipids / blood
Multiple Organ Failure / blood,  etiology,  immunology
Platelet Activating Factor / biosynthesis
Prospective Studies
Thromboxane B2 / blood
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Cytokines; 0/Inflammation Mediators; 0/Interleukin-6; 0/Interleukin-8; 0/Lipids; 0/Platelet Activating Factor; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 71160-24-2/Leukotriene B4; 72025-60-6/Leukotriene C4

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