Document Detail

Are lethal audiogenic seizures a missing link to the sudden infant death syndrome?
MedLine Citation:
PMID:  15193355     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of human seizure disorders has largely been derived from rodent models. A number of rodent and chick strains exhibit a genetic predisposition for lethal audiogenic seizures (AGSs) in the first year of life. Consideration is warranted that this disorder may be linked to the sudden infant death syndrome (SIDS). Factors that carry a strong association with SIDS such as hyperthermia and the prone sleeping position would conceivably play a significant role in a human AGS syndrome. Importantly, there is data to support the likelihood that motor seizure activity may be absent in infants with an AGS syndrome. Rodent AGSs may hold important clues to unraveling the mystery of SIDS.
Daniel D Rubens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  63     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-14     Completed Date:  2005-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  87-91     Citation Subset:  IM    
Department of Anesthesia and Critical Care, Children's Hospital and Regional Medical Center, University of Washington, School of Medicine, 4800 Sand Point Way NE, Seattle, WA 98105, USA.
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MeSH Terms
Epilepsy, Reflex / complications*,  genetics*,  mortality,  physiopathology
Genetic Predisposition to Disease / epidemiology,  etiology,  genetics*
Hypothermia / complications*,  genetics*,  mortality,  physiopathology
Infant, Newborn
Sudden Infant Death / epidemiology,  etiology*,  genetics*

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