Document Detail


Are irreversible morpholocical signs of portal hypertension in neurological form of Wilson's disease associated with treatment delay? A pilot study.
MedLine Citation:
PMID:  22426664     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim of this study was to evaluate the rate of morphological liver and spleen abnormalities in patients with neurological clinical presentation of Wilson's disease (WD). Fourteen patients with neurological presentation of WD divided into group A (5 patients who initiated chelating therapy <24 months from the first symptoms) and group B (9 patients whose therapy started ≥24 months after the initial symptoms) underwent abdominal MRI examination. Abnormal findings on abdominal MRI were present in 28% of patients with neurological form of WD. Significant hepatosplenomegaly was present in none of the patients from group A and in 4 (44%) patients from group B. In addition, macronodular liver cirrhosis and peritoneal effusion were evident in two and one patient from group B, respectively, and in none of the patients from group A. Our results suggest that severe portal hypertension and liver damage in patients with neurological presentation of WD might be reversible or do not even develop if chelating treatment is initiated <2 years after the onset of symptoms.
Authors:
D B Kozic; R Semnic; I Petrovic; M Svetel; J Ostojic; V S Kostic
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-26
Journal Detail:
Title:  Acta neurologica Belgica     Volume:  -     ISSN:  0300-9009     ISO Abbreviation:  Acta Neurol Belg     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-3-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247035     Medline TA:  Acta Neurol Belg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Institute of Oncology, Institutski put 4, 21204, Sremska Kamenica, Serbia, dusko.b.kozic@gmail.com.
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